Expression of the antiphospholipid antibody in patients with systemic lupus erythematosus
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摘要: 目的: 探讨系统性红斑狼疮(SLE)患者的抗磷脂抗体(APA)水平及凝血指标纤维蛋白原(FIB)、D-二聚体(D-D)表达与易栓状态的相关性。方法: 92例SLE患者和30例正常对照者取静脉全血,应用ELISA法检测APA的表达水平,应用磁珠法检测FIB、D-D的表达水平。结果: SLE患者初治、活动期和稳定期APA、FIB、D-D的表达均显著高于对照组(P<0.05);稳定期上述指标均低于初治期和活动期(P<0.05);APA水平与凝血指标FIB、D-D表达呈同步增高趋势。结论: SLE患者伴有凝血功能紊乱,APA水平的异常表达为导致SLE易栓症的重要因素之一。Abstract: Objective: To study the correlation between the expression of the antiphospholipid antibody (APA) and thrombophilia state in systemic lupus erythematosus (SLE) patients by observing the levels of APA,coagulation indicators fibrinogen (FIB) and D-dimer (D-D).Method: Venous whole blood was collected from 92 SLE patients and 30 normal controls.ELISA assay was used to observe the expressions of APA.Method of magnetic beads was used to observe the levels of FIB and D-D.Result: The expressions of APA,FIB and D-D in naive,active and stable patients were significantly higher than those in the controls (P<0.05).The expressions of these indicators in stable patients were lower than those in naive and active patients (P<0.05).The expression of APA,FIB and D-D exhibited synchronizedly increasing trend.Conclusion: SLE patients have coagulation disorders.The abnormal expression of APA is one of the important factors for thrombophilia in SLE patients.
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