A case report of chronic lymphoproliferative disorders of natural killer cells and literature review
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关键词:
- 慢性NK细胞增殖性疾病 /
- 大颗粒淋巴细胞 /
- 自然杀伤细胞
Abstract: The phenomenon of persistent natural killer(NK)cell lymphocytosis has been recognized as the provisional diagnostic entity'chronic lymphoproliferative disorder of natural killer cells'(CLPD-NK)in the WHO classification of hematopoietic tumors.However,disease recognition is problematic because NK cells lack a uniquely rearranged antigen receptor gene(such as T-cell receptor)to serve as a marker of clonal cellular expansion and to facilitate distinction from reactive processes.The paucity of literature suggests that CLPD-NK is rare.Here we report a case of CLPD-NK and discuss it with the relevant literatures. -
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