继发于乳腺癌的治疗相关性伴t（9;11）（p22;q23）;（MLLT3-MLL）急性单核细胞白血病1例并文献复习

李叶琼; 包慎; 冶秀鹏; 魏玉萍; 丁建华

doi:10.13201/j.issn.1004-2806.2016.03.021

继发于乳腺癌的治疗相关性伴t（9;11）（p22;q23）;（MLLT3-MLL）急性单核细胞白血病1例并文献复习

- 1 宁夏人民医院(银川, 750002);
- 2 西北民族大学第一临床学院
基金项目:
宁夏自治区对外科技合作项目资助(No:宁科技字201420)

宁夏自然科学基金项目资助(No:NZ14182)

详细信息

通讯作者: 包慎,E-mail:814764365@qq.com

中图分类号: R733.71

收稿日期: 2015-06-29

A case of the t(9;11)(p22;q23);(MLLT3-MLL) breast cancer treatment-related acute monocytic leukemia and literature review

More Information

Corresponding author: BAO Shen, E-mail: 814764365@qq.com

Received Date: 29 June 2015

摘要

- 乳腺癌 /
- 治疗相关性白血病 /
- 急性单核细胞白血病 /
- t(9 /
- 11)(p22 /
- q23)急性髓细胞白血病 /
- MLLT3-MLL融合基因
Abstract: To explore clinical features,diagnosis and treatment of solid tumor treatment-related acute monocytic leukemia(M₅)with 11q23,we analyzed a case of the breast cancer treatment-related M₅ with t(9;11)(p22;q23);(MLLT3-MLL),and carried on the literature review.The patient was treated with 6cycles of chemotherapy of TEC regimens one year ago.She was admitted with acute leukemia,the myeloproliferation was extremely active,with immature monocytes and mature monocytes accounting for 62% and 31%,respectively.Karyotype analysis was 46,XX,t(9;11)(p22;q23)[20],and MLLT3-MLL was positive.According to classification rules of WHO2008 hematopoietic system disease,she was diagnosed as AML with t(9;11)(p22;q23)abnormality.Because of the patient with a preliminary history of breast cancer chemotherapy,11q23 MLL gene rearrangement could be found in a shorter incubation period of treatment-related leukemia,so the patient was diagnosed as treatment-related M₅ with 11q23/MLL.The breast cancer treatment-related M₅ with t(9;11)(p22;q23);(MLLT3-MLL)is clinically rare,11q23 MLL gene rearrangement suggest that patients belong to a shorter incubation period of treatment-related leukemia,the prognosis is poor.We should strengthen the understanding of this disease.
- breast cancer /
- treatment-related leukemia /
- acute monocytic leukemia /
- t(9 /
- 11)(p22 /
- q23)acute myeloid leukemia /
- MLLT3-MLL fusion gene

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参考文献(8)

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