脂肪组织在急性淋巴细胞白血病耐药中的作用

薛正彪; 王淑芳; 李慧慧; 余莉

doi:10.13201/j.issn.1004-2806.2016.03.026

脂肪组织在急性淋巴细胞白血病耐药中的作用

- 南昌大学第二附属医院血液内科(南昌, 330000)
基金项目:
国家自然科学基金(No:81460030)

详细信息

通讯作者: 余莉,E-mail:zengyulii@126.com

中图分类号: R733.71

收稿日期: 2015-04-13

The role of adipose tissue-derived treatment in resistant acute lymphoblastic leukemia

More Information

Corresponding author: YU Li, E-mail: zengyulii@126.com

Received Date: 13 April 2015

摘要

- 脂肪组织 /
- 肿瘤微环境 /
- 白血病,淋巴细胞,急性 /
- 肥胖症 /
- 耐药性
Abstract: Epidemiological studies have shown that there is a connection between obesity and the prognosis in pediatric acute lymphoblastic leukemia(ALL).Compared with the body lean group,the incidence of minimal residual disease in the obese group is 2.50 to 2.75 times higher,and 5-year disease-free survival in the obese group is significantly shorter.Adipose tissue plays an active role in many types of tumor microenvironment.Recently,it has been discovered that adipose tissue plays a special role in the development,treatment and prognosis of ALL through a variety of ways.In addition,the biological field of adipose tissue has also made a breakthrough.This paper is a brief review that how the adipose tissue affect the curative effect,prognosis and resistant mechanism of the patients with ALL.
- adipose tissue /
- tumor microenvironments /
- acute lymphoblastic leukemia /
- obesity /
- drug-resistance

HTML全文

参考文献(26)

[1]	王增武,郝光,王馨,等.我国中年人群超重/肥胖现况及心血管病危险因素聚集分析[J].中华流行病学杂志,2014,35(4):354-358.
[2]	Flegal KM,Graubard BI,Williamson DF,et al.Cause-specific excess deaths associated with underweight,overweight,and obesity[J].JAMA,2007,298:2028-2037.
[3]	Hanahan D,Coussens LM.Accessories to the crime:functions of cells recruited to the tumor microenvironment[J].Cancer Cell,2012,21:309-322.
[4]	Orgel E,Tucci J,Alhushki W,et al.Obesity is associated with residual leukemia following induction therapy for childhood B-precursor acute lymphoblastic leukemia[J].Blood,2014,124:3932-3938.
[5]	Zhang Y,Proenca R,Maffei M,et al.Positional cloning of the mouse obese gene and its human homologue[J].Nature,1994,372:425-432.
[6]	Trayhurn P,Wood IS.Adipokines:inflammation and the pleiotropic role of white adipose tissue[J].Br J Nutr,2004,92:347-355.
[7]	Tan J,Buache E,Chenard MP,et al.Adipocyte is a non-trivial,dynamic partner of breast cancer cells[J].Int J Dev Biol,2011,55:851-859.
[8]	Duffaut C,Galitzky J,Lafontan M,et al.Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity[J].Biochem Biophys Res Commun,2009,384:482-485.
[9]	Ouchi N,Parker JL,Lugus JJ,et al.Adipokines in inflammation and metabolic disease[J].Nat Rev Immunol,2011,11:85-97.
[10]	Larsson SC,Wolk A.Overweight and obesity and incidence of leukemia:a meta-analysis of cohort studies[J].Int J Cancer,2008,122:1418-1421.
[11]	Butturini AM,Dorey FJ,Lange BJ,et al.Obesity and outcome in pediatric acute lymphoblastic leukemia[J].J Clin Oncol,2007,25:2063-2069.
[12]	Hijiya N,Panetta JC,Zhou Y,et al.Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia[J].Blood,2006,108:3997-4002.
[13]	Vicente LA,Vazquez GM,Melen GJ,et al.Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production:correlations with the course of disease[J].PLoS One,2014,9:e84496.
[14]	Behan JW,Yun JP,Proektor MP,et al.Adipocytes impair leukemia treatment in mice[J].Cancer Res,2009,69:7867-7874.
[15]	Pramanik R,Sheng X,Ichihara B,et al.Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy[J].Leuk Res,2013,37:503-509.
[16]	Battula VL,Chen Y,Cabreira MG,et al.Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment[J].Blood,2013,122:357-366.
[17]	Beaulieu A,Poncin G,Belaid-Choucair Z,et al.Leptin reverts pro-apoptotic and antiproliferative effects of alpha-linolenic acids in BCR-ABL positive leukemic cells:involvement of PI3K pathway[J].PLoS One,2011,6:e25651.
[18]	Dirat B,Bochet L,Dabek M,et al.Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion[J].Cancer Res,2011,71:2455-2465.
[19]	Zhang Y,Daquinag AC,Amaya-Manzanares F,et al.Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment[J].Cancer Res,2012,72:5198-5208.
[20]	Klopp AH,Zhang Y,Solley T,et al.Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors[J].Clin Cancer Res,2012,18:771-782.
[21]	Nieman KM,Kenny HA,Penicka CV,et al.Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth[J].Nat Med,2011,17:1498-1503.
[22]	Ehsanipour EA,Sheng X,Behan JW,et al.Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine[J].Cancer Res,2013,73:2998-3006.
[23]	Brill MJ,Diepstraten J,Van Rongen A,et al.Impact of obesity on drug metabolism and elimination in adults and children[J].Clin Pharmacokinet,2012,51:277-304.
[24]	Behan JW,Avramis VI,Yun JP,et al.Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice[J].Pharmacol Res,2010,61:385-390.
[25]	Griggs JJ,Mangu PB,Anderson H,et al.Appropriate chemotherapy dosing for obese adult patients with cancer:American Society of Clinical Oncology clinical practice guideline[J].J Clin Oncol,2012,30:1553-1561.
[26]	Adami HO,Trichopoulos D.Obesity and mortality from cancer[J].N Engl J Med,2003,348:1623-1624.