Relationship and significance of CD68 expression and microvessel density in microenvironment of diffuse large B-cell lymphoma
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摘要: 目的:探讨弥漫大B细胞淋巴瘤(DLBCL)微环境中CD68表达与微血管密度(MVD)的关系及意义。方法:通过免疫组织化学方法检测77例DLBCL组织中CD68与CD34的表达,分析肿瘤相关巨噬细胞、MVD与患者临床病理指标的关系及二者的相关性。结果:CD68与患者年龄(P=0.016)及国际预后指数(IPI)有关(P=0.002),MVD与肿瘤原发部位(P=0.002)及IPI有关(P=0.030),且MVD与肿瘤微环境中CD68的表达呈正相关(r=0.290,P=0.010)。结论:肿瘤相关巨噬细胞与DLBCL肿瘤血管生成有关,CD68与MVD的高表达均提示患者预后较差。Abstract: Objective:To investigate the relationship and significance of CD68 expression and microvessel density (MVD) in microenvironment of diffuse large B-cell lymphoma (DLBCL).Method:Immunohistochemical staining was used to detect the expression of CD68 and CD34 in DLBCL patients (n=77) to analyze the relationship between tumor-associated macrophage and MVD and their correlations with clinicopathological parameters.Result:CD68 was associated with patient's age (P=0.016) and international prognostic index (IPI)(P=0.002).MVD was associated with primary site (P=0.002) and IPI (P=0.030).MVD was positively correlated with CD68 expression (r=0.290,P=0.010).Conclusion:Tumor-associated macrophage is associated with tumor angiogenesis in DLBCL.Both high expression of CD68 and high MVD indicate adverse prognosis of DLBCL patients.
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[1] 朱明霞,万文丽,洪韫,等.CD43在弥漫大B细胞淋巴瘤中的表达及临床意义[J].临床血液学杂志,2018,31(5):343-347.
[2] 陈艳欣,郑晓云,刘庭波,等.利妥昔单抗联合CHOP与单用CHOP方案治疗初治弥漫大B细胞淋巴瘤疗效及安全性对比[J].临床血液学杂志,2015,28(9):760-763.
[3] 金静霞,郑翠苹,陈丽雅,等.PD-1、PD-L1在弥漫大B细胞淋巴瘤组织中的差异性表达及其临床意义[J].临床血液学杂志,2018,31(1):34-37.
[4] Cai QC,Liao H,Lin SX,et al.High expression of tumor-infiltrating macrophages correlates with poor prognosis in patients with diffuse large B-cell lymphoma[J].Med Oncol,2012,29:2317-2322.
[5] Guo B,Cen H,Tan X,et al.Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma[J].BMC Med,2016,14:159.
[6] Komohara Y,Niino D,Ohnishi K,et al.Role of tumor-associated macrophages in hematological malignancies[J].Pathol Int,2015,65:170-176.
[7] Ronca R,Benkheil M,Mitola S,et al.Tumor angiogenesis revisited:Regulators and clinical implications[J].Med Res Rev,2017,37:1231-1274.
[8] Mantovani A,Sica A.Macrophages,innate immunity and cancer:balance,tolerance,and diversity[J].Curr Opin Immunol,2010,22:231-237.
[9] Jelicic J,Balint MT,Jovanovic MP,et al.The role of lymphocyte to monocyte ratio,microvessel density and high CD44 tumor cell expression in non Hodgkin lymphomas[J].Pathol Oncol Res,2016,22:567-577.
[10] Zhao X,Qu J,Sun Y,et al.Prognostic significance of tumor-associated macrophages in breast cancer:a meta-analysis of the literature[J].Oncotarget,2017,8:30576-30586.
[11] Jackaman C,Tomay F,Duong L,et al.Aging and cancer:The role of macrophages and neutrophils[J].Ageing Res Rev,2017,36:105-116.
[12] 李延莉.单核巨噬细胞系统在弥漫大B细胞淋巴瘤发生发展中作用的临床和实验研究[D].安徽医科大学,2015.
[13] Krishna Priya S,Nagare RP,Sneha VS,et al.Tumour angiogenesis-origin of blood vessels[J].Int J Cancer,2016,139:729-735.
[14] Jian ZW,Yu JX,Man GCW,et al.Clinicopathological and prognostic significance of blood microvessel density in endometrial cancer:a meta-analysis and subgroup analysis[J].Arch Gynecol Obstet,2018,297(Suppl 4):1-10.
[15] Hong WG,Ko YS,Pyo JS.Clinicopathological significance and prognostic role of microvessel density in gastric cancer:A meta-analysis[J].Pathol Res Pract,2017,213:1459-1463.
[16] Ma G,Zhang J,Jiang H,et al.Microvessel density as a prognostic factor in esophageal squamous cell cancer patients:A meta-analysis[J].Medicine (Baltimore),2017,96:e7600.
[17] 吴静怡,曹阳,孙立石,等.非霍奇金淋巴瘤组织中FGFR3和VEGF的表达及其与血管生成的相关性[J].肿瘤防治研究,2009,36(3):225-228.
[18] Cardesa-Salzmann TM,Colomo L,Gutierrez G,et al.High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy[J].Haematologica,2011,96:996-1001.
[19] Wu H,Xu J,He Y,et al.Tumor-associated macrophages promote angiogenesis and lymphangiogenesis of gastric cancer[J].J Surg Oncol,2012,106:462-468.
[20] 智敏.肿瘤相关巨噬细胞在肿瘤发展中的作用[J].中外医疗,2012,31(12):186-187.
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