海岛地区合并HBV感染的非霍奇金淋巴瘤临床研究

竺枫; 王宏强; 杨序春

doi:10.13201/j.issn.1004-2806.2019.03.012

海岛地区合并HBV感染的非霍奇金淋巴瘤临床研究

- 舟山医院血液科(浙江舟山, 316000)

详细信息

通讯作者: 杨序春,E-mail:yangblood@163.com

中图分类号: R733.4

收稿日期: 2018-11-22

Clinical study of non-Hodgkin’s lymphoma with HBV infection in island area

- Department of Hematology, Zhoushan Hospital, Zhoushan, 316000, China

More Information

Corresponding author: YANG Xuchun, E-mail: yangblood@163.com

Received Date: 22 November 2018

摘要

摘要: 目的:探讨非霍奇金淋巴瘤(NHL)与乙肝病毒(HBV)感染的相关性,以及合并HBV感染NHL的临床特征。方法:收集初诊NHL 312例,采用ELISA法检测HBV感染状态,并分析HBsAg阳性组和HBsAg阴性组的临床特征和治疗结果。结果:NHL患者HBsAg阳性率明显高于同期住院治疗的肿瘤患者(排除肝癌),临床特征中性别、年龄与乙肝感染相关性不大,不同病理类型中以弥漫大B细胞淋巴瘤HBsAg阳性率最高,差异有统计学意义(P<0.05)。HBsAg阳性组分期晚,治疗后有效率低,中位生存时间短,与HBsAg阴性组比较差异有统计学意义(P<0.05)。结论:HBV与NHL发病有一定的相关性,合并HBV感染的NHL预后较差。
- 海岛地区 /
- 非霍奇金淋巴瘤 /
- 乙肝病毒
Abstract: Objective:To investigate the correlation between non-Hodgkin's lymphoma (NHL) and hepatitis B virus (HBV) infection and the clinical features of NHL complicated with HBV infection.Method:A total of 312 cases of newly diagnosed NHL were enrolled.The infection status of HBV was detected by ELISA.The clinical characteristics and treatment results of HBsAg positive group and HBsAg negative group were analyzed.Result:The positive rate of HBsAg in NHL patients was significantly higher than in patients with other tumors in the same period of hospitalization (excluding hepatocellular carcinoma).There was no significant correlation among gender,age and hepatitis B infection.Diffuse large B-cell lymphoma had the highest positive rate among different types of NHL patients,and the difference was statistically significant (P<0.05).The patients in HBsAg positive group showed a late stage,a low effective rate and a short median survival time after treatment.There was significant difference between HBsAg positive group and HBsAg negative group (P<0.05).Conclusion:There is an unequivocal correlation between HBV infection and NHL pathogenesis.The prognosis of NHL with HBV infection is poor.
- island area /
- non-Hodgkin’s lymphoma /
- hepatitis B virus

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