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单克隆IgM及IgG共存的淋巴浆细胞淋巴瘤1例并文献复习

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文章导航 > 临床血液学杂志 > 2019 > 32(3): 219-221
何靖, 胡莉文, 古学奎, 等. 单克隆IgM及IgG共存的淋巴浆细胞淋巴瘤1例并文献复习[J]. 临床血液学杂志, 2019, 32(3): 219-221. doi: 10.13201/j.issn.1004-2806.2019.03.015
引用本文: 何靖, 胡莉文, 古学奎, 等. 单克隆IgM及IgG共存的淋巴浆细胞淋巴瘤1例并文献复习[J]. 临床血液学杂志, 2019, 32(3): 219-221. doi: 10.13201/j.issn.1004-2806.2019.03.015
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HE Jing, HU Liwen, GU Xuekui, et al. Lymphoplasmacytic lymphoma with the coexistence of monoclonal IgM-Kappa and IgG-Kappa:a case report and literature review[J]. J Clin Hematol, 2019, 32(3): 219-221. doi: 10.13201/j.issn.1004-2806.2019.03.015
Citation: HE Jing, HU Liwen, GU Xuekui, et al. Lymphoplasmacytic lymphoma with the coexistence of monoclonal IgM-Kappa and IgG-Kappa:a case report and literature review[J]. J Clin Hematol, 2019, 32(3): 219-221. doi: 10.13201/j.issn.1004-2806.2019.03.015
shu

单克隆IgM及IgG共存的淋巴浆细胞淋巴瘤1例并文献复习

    • 1. 广州中医药大学第一附属医院血液科(广州, 510405);

    • 2. 华中科技大学同济医学院附属协和医院血液科

详细信息
    通讯作者: 黎纬明,E-mail:lee937@126.com

  • 中图分类号: R733.4

Lymphoplasmacytic lymphoma with the coexistence of monoclonal IgM-Kappa and IgG-Kappa:a case report and literature review

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    摘要
  • To understand a rare type of lymphoplasmacytic lymphoma (LPL) with the coexistence of monoclonal IgM and IgG,we reported one case of LPL with the coexistence of monoclonal IgM and IgG,and retrospectively reviewed three similar cases.The concentration of IgG was higher than that of IgM in three of the four patients,and lower than that of IgM in the other patient.Rituximab based treatment had a better short-term theraputic effect than the treatment without Rituximab.The LPL which exhibits a coexistence of monoclonal IgM and IgG is rare.The pathogenesis of this disease is still unknown,although it has similar clinical features,response to treatment,as well as prognosis with monoclonal LPL.In this case the combination of Rituximab,fludarabine and cyclophosphamide (RFC) might have shorter time to the best response and less serious infection compared with previous cases.
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    • 参考文献(6)
  • [1]

    Shin SY,Lee ST,Kim SH,et al.Detection of MYD88L256P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas[J].Blood Res,2016,51:181-186.

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    Bakkus MHC,Schots R,Van Camp B,et al.Clonally related IgA-and IgE-secreting plasma cells in a myeloma patient[J].Eur J Haematol,2000,65:348-355.

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    Ahmad TM,Alaleh E,Michelle KZ,et al.Concomitant lymphoplasmacytic lymphoma and plasma cell myeloma,a diagnostic challenge[J].Am J Blood Res,2017,7:10-17.

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    Guastafierro S,Ferrara MG,Falcone U,et al.Clinical significance of serum triple monoclonal components:a report of 6 cases and a review of the literature[J].Leuk Res,2014,38:166-169.

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    Souchet L,Levy V,Ouzegdouh M,et al.Efficacy and long-term toxicity of the rituximab-fludarabine-cycolphosphamide combination therapy in Waldenstrom's macroglobulinemia[J].Am J Hematol,2016,91:782-786.

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    Mullikin TC,Rajkumar SV,Russell SJ,et al.Clinincal characteristics and out-comes in biclonal gammopathies[J].Am J Hematol,2016,91:473-475.

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收稿日期:  2017-12-10

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