Recurrence and evolution of donor-derived myeloid neoplasm after unrelated hematopoietic stem cell transplantation:one case report and literature review
-
Abstract: We report the case of a man with acute erythroleukemia (AML-M6),who developed myelodysplastic syndrome 8 years after HLA-matched unrelated bone marrow transplantation.Its donor cell origin proved by molecular analysis using short tandem repeat sequences.To our knowledge,this is the first case who the demethylation drug were used in donor-cell-derived leukemia patient.
-
-
[1] Wiseman DH.Donor cell leukemia:a review[J].Biol Blood Marrow Transplant,2011,17:771-789.
[2] Wang E,Hutchinson CB,Huang Q,et al.Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients:a clinicopathologic study of 10 cases and a comprehensive review of the literature[J].Am J Clin Pathol,2011,135:525-540.
[3] Hertenstein B,Hambach L,Bacigalupo A,et al.Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT)[J].Haematologica,2005,90:969-975.
[4] Berg KD,Brinster NK,Huhn KM,et al.Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation[J].N Engl J Med,2001,345:1458-1463.
[5] Yasuda T,Ueno T,Fukumura K,et al.Leukemic evolution of donorderived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation[J].Leukemia,2014,28:426-428.
[6] Xiao H,Shi J,Luo Y,et al.First report of multiple CEBPA mutations contributing to donor origin of leukemia relapse after allogeneic hematopoietic stem cell transplantation[J].Blood,2011,117:5257-5260.
[7] Berger G,van den Berg E,Sikkema-Raddatz B,et al.Re-emergence of acute myeloid leukemia in donor cells following allogeneic transplantation in a family with a germline DDX41 mutation[J].Leukemia,2017,31:520-522.
[8] Kobayashi S,Kobayashi A,Osawa Y,et al.Donor cell leukemia arising from preleukemic clones with a novel germline DDX41 mutation after allogenic hematopoietic stem cell transplantation[J].Leukemia,2017,31:1020-1022.
[9] Kato M,Yamashita T,Suzuki R,et al.Donor cell-derived hematological malignancy:a survey by the Japan Society for Hematopoietic Cell Transplantation[J].Leukemia,2016,30:1742-1745.
[10] Shiozaki H,Yoshinaga K,Kondo T,et al.Donor cell-derived leukemia after cord blood transplantation and a review of the literature:differences between cord blood and BM as the transplant source[J].Bone Marrow Transplantation,2014,49:102-109.
[11] Flynn CM,Kaufman DS.Donor cell leukemia:insight into cancer stem cells and the stem cell niche[J].Blood,2007,109:2688-2692.
[12] 夏凌辉,张然.急性白血病异基因造血干细胞移植后复发的新药治疗[J].临床血液学杂志,2018,31(9):664-668.
[13] Suárez-González J,Martínez-Laperche C,Kwon M,et al.Donor cell-derived hematological neoplasms after hematopoietic stem cell transplantation:a systematic review[J].Biol Blood Marrow Transplant,2018,24:1505-1513.
-
计量
- 文章访问数: 381
- PDF下载数: 238
- 施引文献: 0