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Abstract: To explore the diagnosis,treatment and prognosis of BCR-ABL positive acute myeloid leukemia（AML）,we reported a case of BCR-ABL positive AML with clinical features,diagnosis,treatment,prognosis and reviewed the related literature.The patient was a 64-year-old male with a history of 1 month.He had dizziness and nausea as the first manifestation.Blood routine examination showed that hemoglobin reduction and thrombocytopenia,while white blood cells were normal.Primordial cells accounted for 23.5%;immunophenotype showed that CD34,CD117,CD123,CD38 were positive;PCR showed BCR/ABL positive（P190）;the chemotherapy of decitabine combined with CIG had not achieve complete remission,but decitabine combined with DA and tyrosine kinase inhibitor had.The patient treated with tyrosine kinase inhibitor and Bcl-2 inhibitor for maintenance treatment.The disease was in remission for more than 3 months.BCR-ABL positive AML is rare type in clinic,and there is no unified treatment plan.The elderly patients can not tolerate standard chemotherapy and hematopoietic stem cell transplantation.Targeted therapy is expected to improve the survival of patients.
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Key words:
- acute myeloid leukemia /
- BCR-ABL /
- treatment
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