肿瘤来源外泌体对白血病疾病进展的调控作用及机制

王培龙; 李姮

doi:10.13201/j.issn.1004-2806.2020.11.016

肿瘤来源外泌体对白血病疾病进展的调控作用及机制

王培龙,
李姮^,

- 中南大学湘雅二医院分子血液病研究中心(长沙, 410000)
基金项目:
国家自然科学基金青年科学基金项目(No:81800198)

详细信息

通讯作者: 李姮,E-mail:liheng001@csu.edu.cn

中图分类号: R733.7

收稿日期: 2020-05-08

The mechanism of tumor-derived exosomes in the regulation of leukemia progression

WANG Pei-long,
LI Heng^,

More Information

Corresponding author: LI Heng, E-mail: liheng001@csu.edu.cn

Received Date: 08 May 2020

摘要

- 外泌体 /
- 白血病 /
- 骨髓微环境
Abstract: Exosomes are 30-150 nm lipid bilayer vesicles containing biological constituents such as proteins,lipids,nucleic acids.Exosomes are secreted in most body fluids and transfer kinds of cargos to cells,participating in intercellular communication.Leukemia derived exosomes can alter normal bone marrow to tumor-supporting microenvironment and suppress hematopoietic cells,immune cells functions.Exosomes play important roles in supporting tumor growth,immune regulation,drug resistance and tremendously contribute to the development of leukemia.
- exosomes /
- leukemia /
- tumor microenvironment

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参考文献(36)

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