Risk factors,prevention and treatment of bleeding complications of myeloproliferative neoplasm
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Abstract: Philadelphia chromosome-negative myeloproliferative neoplasm(MPN)is a clonal hematological malignant tumor of the hematopoietic stem cell,which includes polycythemia vera,essential thrombocythemia and primary myelofibrosis.MPN has a chronic course of disease,and the prognosis of patients mainly depends on the complications of thrombosis and bleeding and transformation of myelofibrosis and leukemia.Among them,bleeding is a common complication of MPN,but it is easy to be ignored by clinicians.Recent studies have shown that the prevalence of hemorrhagic complications in newly diagnosed MPN patients is as high as 6.2%.The causes of bleeding in patients with MPN are various.Abnormal blood cell count,JAK2 gene mutation and the use of antiplatelet agents such as aspirin will increase the risk of bleeding.The purpose of this article is to explain the risk factors of bleeding complications in patients with MPN,to explore how to balance the risk of bleeding and the benefits of treatment,and to put forward suggestions for prevention and treatment.
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Key words:
- myeloproliferative neoplasm /
- bleeding /
- risk factors /
- treatment
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