Analysis of prognostic value of hematopoietic indices in patients with multiple myeloma
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摘要: 目的:回顾性分析平均红细胞体积、血红蛋白及血小板计数组成的造血评分(HS)系统对初诊多发性骨髓瘤(MM)患者的预后价值。方法:收集整理2012年2月至2019年1月我院血液科收治的179例新诊断MM患者的临床资料及生存情况。根据HS系统将所有患者分为0,1,2,3分共4组,通过受试者工作特性曲线分析得出最佳截断值,将HS系统分为高分组(2~3分)和低分组(0~1分)。利用χ2检验比较组间差异,生存率的计算和比较采用Kaplan-Meier法和Log-rank检验,使用Cox回归进行单因素、多因素预后相关性分析。结果:高分组与低分组在年龄、β2-微球蛋白、乳酸脱氢酶、ISS分期、DS分期方面差异有统计学意义(P<0.05)。单因素分析结果显示,年龄、血红蛋白、血小板计数、乳酸脱氢酶、ISS分期、DS分期、β2-微球蛋白、HS、白蛋白、骨髓浆细胞比例是MM的不良预后因素(P<0.05)。多因素Cox分析模型表明,HS、年龄、白蛋白、乳酸脱氢酶、骨髓浆细胞是影响MM患者总生存的独立危险因素(P<0.05)。结论:初诊时HS越高提示预后不良,是MM的独立危险因素。Abstract: Objective: To retrospectively analyze the prognostic value of the hematopoietic score(HS) system composing mean red blood cell volume, hemoglobin and platelet count for newly diagnosed multiple myeloma(MM) patients.Methods: The clinical data and survival status of 179 newly diagnosed MM patients admitted to our hospital from February 2012 to January 2019 were collected. According to the HS system, patients were divided into four groups of 0, 1, 2, and 3 points. The best cut-off value was obtained through receiver operating characteristic curve analysis, and based on the HS system, it was divided into higher points group(2-3 points) and lower points group(0-1 points). We used the χ2test to compare the differences between groups, the Kaplan-Meier method and Log-rank test to calculate and compare the survival rate, and the Cox regression to analyze the univariate and multivariate prognostic correlation.Results: There were statistically significant differences between the higher and lower points groups in age, β2-microglobulin, lactate dehydrogenase, ISS staging, and DS staging(P<0.05). The results of univariate analysis showed that age, hemoglobin, platelet count, lactate dehydrogenase, ISS staging, DS staging, β2-microglobulin, HS, albumin, bone marrow plasma cell ratio were related to poor prognostic factors of MM(P<0.05). Multivariate Cox analysis model showed that HS, age, albumin, lactate dehydrogenase, bone marrow plasma cells were independent risk factors that affect overall survival of MM patients(P<0.05).Conclusion: The higher the HS at the first diagnosis, the poor prognosis, which is an independent risk factor of MM.
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Key words:
- multiple myeloma /
- hematopoietic score /
- prognostic
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