Abstract: Objective: To analyze relevant information on HLA-B^*51: 36 which was first found by the Hangzhou Blood Center in 2004.Methods: We performed low-and medium-resolution DNA typing of human leukocyte antigen(HLA)-A, B and DR alleles using polymerase chain reaction/sequence-specific primer or sequence-specific oligonucleotide prode and analyzed correlating information of HLA-B^*51: 36. At the same time, we identified the HLA-B^*51: 36 phenotype of one sample by the microlymphocytotoxicity test.Results: We detected 34 cases of HLA-B^*51: 36 within 50 000 voluntary donors of Liaoning hemopoietic stem cell or platelet from 2004 to 2018.Conclusion: The results showed that HLA-B^*51: 36-DR01 expressed strong linkage disequilibrium. However, in Liaoning, HLA-B^*51-DR^*01 trabant expressed no relationship of linkage. Our study suggested that DRB1^*01 may prompt B^*51: 08 gene site-specific mutation into gene type B^*51: 36. The phenotype of the sample which had the HLA-B^*51: 36 carried three HLA-B antigens, B44, B51 and B37. We need more samples to test so that we can analyze the causation of triple HLA-B antigen in the detected sample or the HLA-B^*51: 36 allele.