JAG1联合lncRNA lucat1检测对结直肠癌患者疗效的判定及影响患者生存率的危险因素分析

董颖; 王琳

doi:10.13201/j.issn.1004-2806.2021.04.005

JAG1联合lncRNA lucat1检测对结直肠癌患者疗效的判定及影响患者生存率的危险因素分析

董颖,
王琳^,

- 如皋市人民医院检验科(江苏如皋,226500)
基金项目:
南通市科研计划项目(指导性)(No:WKZD2018029)

详细信息

通讯作者: 王琳,E-mail:fhsuwj@163.com

中图分类号: R735.3

收稿日期: 2020-08-07

Evaluation of therapeutic effect of JAG1 combined with lncRNA lucat1 in patients with colorectal cancer and analysis of risk factors affecting survival rate

DONG Ying,
WANG Lin^,

- Laboratory of Rugao People's Hospital, Rugao, 226500, China

More Information

Corresponding author: WANG Lin, E-mail: fhsuwj@163.com

Received Date: 07 August 2020

摘要

摘要: 目的:探讨JAG1蛋白联合长链非编码RNA(lncRNA)肺癌相关转录本1(lucat1)检测对结直肠癌患者疗效的判定及影响患者生存率的危险因素。方法:选取2013年3月—2016年10月确诊的120例结直肠癌患者作为研究对象(观察组),另选取同期健康体检人群120例(对照组),运用酶联免疫法和实时荧光定量PCR方法分别对2组的JAG1、lncRNA lucat1水平进行检测,比较不同治疗效果(客观有效组和客观无效组)以及预后(生存组和死亡组)患者的JAG1、lncRNA lucat1水平之间的差异,分析不良预后的危险因素。结果:观察组JAG1、lncRNA lucat1水平显著低于对照组(P<0.05);客观有效组JAG1、lncRNA lucat1水平显著低于客观无效组(P<0.05);生存组JAG1、lncRNA lucat1水平显著低于死亡组(P<0.05);患者的年龄、病程、侵袭深度、临床分型以及DUKE分期均为不良预后的独立危险因素。结论:JAG1联合lncRNA lucat1检测对于结直肠癌患者的疗效的判定以及生存情况具有显著的预测价值。
- 结直肠癌 /
- JAG1 /
- lncRNAlucat1 /
- 生存率 /
- 相关性
Abstract: Objective: To investigate the effect of JAG1 combined with lncRNA lucat1 on colorectal cancer patients and the risk factors of survival rate.Methods: A total of 120 colorectal cancer patients diagnosed in our hospital from March 2013 to October 2016 were selected as the research objects, and 120 healthy people in the same period were selected as the control group. JAG1 and lncRNA lucat1 levels of the two groups were detected respectively, and the differences between JAG1 and lncRNA lucat1 levels of patients with different treatment effects and prognosis were compared, and the risk factors of poor prognosis were analyzed.Results: The levels of JAG1 and lncRNA lucat1 in the observation group was significantly lower than those in the control group(P<0.05); the levels of JAG1 and lncRNA lucat1 in the objective effective group was significantly lower than those in the objective ineffective group(P<0.05); the levels of JAG1 and lncRNA in the survival group was significantly lower than those in the objective ineffective group(P<0.05). The level of lncRNA lucat1 was significantly lower than that of the death group.Conclusion: The detection of JAG1 combined with lncRNA lucat1 might have a significant predictive value for the efficacy and survival of colorectal cancer patients.
- colorectal cancer /
- JAG1 /
- lncRNA lucat1 /
- survival /
- correlation

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参考文献(16)

[1]	陶绍能,王莹莹,杨军,等.LncRNA SNHG11在结直肠癌患者血清中的表达及临床意义[J].实用医学杂志,2020,36(6):792-795.
[2]	王琳,吴慧丽,肖兴国,等.FOXC1和lncRNA FOXCUT在结直肠癌患者中的表达及其对病情进展的影响[J].中国实用医刊,2020,47(1):4-7.
[3]	邓巧玲,柳家翠,喻明霞,等.结直肠癌中LncRNA介导的内源性竞争性RNA调控网络[J].西部医学,2020,32(2):166-170.
[4]	康争春,鄂继福,吕桂芬.结直肠癌相关长链非编码RNA调控信号通路研究进展[J].西部医学,2020,32(2):304-307,312.
[5]	曾理,庄树彤,丁世华,等.长链非编码RNA AFAP1-AS1通过PTEN/p-AKT信号通路调控结直肠癌细胞增殖的分子机制研究[J].实用肿瘤学杂志,2020,34(1):11-16.
[6]	杨学宁,吴一龙.实体瘤治疗疗效评价标准-RECIST[J].循证医学,2004,4(2):25-30,51.
[7]	邓颖,朱宇珍,吴科锋,等.IL-6/STAT3通路介导lncRNAH19上调在小鼠溃疡性结肠炎相关结直肠癌发病中的作用[J].吉林大学学报(医学版),2020,46(1):20-25.
[8]	金洋亦泓,杨继元.长链非编码RNA在结直肠癌转移中的研究进展[J].癌症进展,2020,18(2):128-132.
[9]	Ribeiro TB,Ribeiro A,Rodrigues LO,et al.U.S.Food and Drug Administration anticancer drug approval trends from 2016 to 2018 for lung,colorectal,breast,and prostate cancer[J].Int J Technol Assess Health Care,2020,36(1):20-28.
[10]	Galaine J,Turco C,Vauchy C,et al.CD4 T cells target colorectal cancer antigens upregulated by oxaliplatin[J].Int J Cancer,2019,145(11):3112-3125.
[11]	Sabik LM,Eom KY,Dahman B,et al.The Impact of Massachusetts Health Reform on Colorectal and Breast Cancer Stage at Diagnosis[J].Med Care,2020,58(2):183-191.
[12]	Wenfu Zhou,Weimin Li.The Application of Laparoscopic B-Ultrasound Microwave Ablation Technology in Liver Metastasis of Colorectal Cancer[J].Int J Clini Med,2020,11(2):62-69.
[13]	Chim-Kei.Chan,Kind-Leng.Tong,Pooi-Fong.Wong,et al.Deoxyelephantopin induces ROS-mediated autophagy and apoptosis in human colorectal cancer in vitro and in vivo[J].Asian Pac J Trop Biomed,2020,10(3):120-135.
[14]	Kok DE,Steegenga WT,Smid EJ,et al.Bacterial folate biosynthesis and colorectal cancer risk:more than just a gut feeling[J].Crit Rev Food Sci Nutr,2020,60(2):244-256.
[15]	孙建国.JAG1蛋白表达水平对结直肠癌患者切除术后预后影响的临床研究[J].中国现代普通外科进展,2018,21(8):606-610.
[16]	Wang N,Zeng L,Li Z,et al.Serum miR-663 expression and the diagnostic value in colorectal cancer[J].Artif Cells Nanomed Biotechnol,2019,47(1):2650-2653.