血常规相关参数在慢性乙型肝炎病毒感染性肝病患者预后中的应用

王亚鹏; 王明良; 侯晓禹; 汪洋

doi:10.13201/j.issn.1004-2806.2021.06.013

血常规相关参数在慢性乙型肝炎病毒感染性肝病患者预后中的应用

- 1. 辽宁省健康产业集团抚矿总医院输血科(辽宁抚顺, 113008);
- 2. 辽宁省健康产业集团抚矿总医院检验科

详细信息

通讯作者: 王亚鹏,E-mail:weiweimei66@163.com

中图分类号: R512.6

收稿日期: 2020-11-24

Application of blood routine parameters in prognosis of patients with chronic hepatitis B virus infection related liver disease

- 1. Department Blood Transfusion, Liaoning Health Industry Group Fukuang General Hospital, Fushun, 113008, China;
- 2. Department of Laboratory, Liaoning Health Industry Group Fukuang General Hospital

More Information

Corresponding author: WANG Yapeng, E-mail: weiweimei66@163.com

Received Date: 24 November 2020

摘要

摘要: 目的:探讨血常规相关参数红细胞体积分布宽度(RDW)、单核细胞/淋巴细胞比值(MLR)及血小板(PLT)在慢性乙型肝炎病毒(HBV)感染相关性肝病患者预后中的应用。方法:纳入慢性HBV感染相关性肝病患者126例,其中慢性乙型肝炎(CHB)患者79例(CHB组)和乙型肝炎肝硬化(HBV-LC)患者47例(HBV-LC组)。应用全自动血液细胞分析仪检测血常规,记录RDW、MLR及PLT参数,评估RDW、MLR及PLT参数与慢性HBV感染相关性肝病预后的相关性。结果:HBV-LC组、CHB组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、乙型肝炎e抗原(HBeAg)、RDW、MLR、血小板分布宽度(PDW)、平均血小板体积(MPV)水平均高于对照组(P<0.05),血清蛋白(ALB)、PLT、血小板比容(PCT)水平均低于对照组(P<0.05);且HBV-LC组各指标优于CHB组(P<0.05)。RDW、MLR、MPV与ALT、AST水平呈正相关,与ALB水平呈负相关,MLR与TBIL水平呈正相关,PLT、PCT与ALT、AST、TBIL水平呈正相关,与ALB水平呈负相关。肝脏硬度值(LSM)与RDW、MLR、MPV呈正相关,与PLT、PCT呈负相关。预后不良组患者RDW、MLR、PDW、MPV水平高于预后良好组(P<0.05),PLT、PCT水平低于预后良好组。结论:RDW、MLR及PLT参数可能是评估慢性HBV感染相关性肝病病情程度及预后的有效指标,值得推广和应用。
- 乙型肝炎病毒 /
- 肝病 /
- 红细胞分布宽度 /
- 单核细胞/淋巴细胞比值 /
- 血小板参数
Abstract: Objective: To investigate the application of red blood cell volume distribution width(RDW), monocyte to lymphocyte ratio(MLR) and platelet parameters in the prognosis of patients with chronic hepatitis B virus(HBV) infection related liver disease.Methods: A total of 126 patients with chronic HBV infection related liver disease were enrolled, including 79 patients with chronic hepatitis B(CHB group) and 47 patients with hepatitis B cirrhosis(HBV-LC group). The RDW, MLR and platelet parameters were recorded to evaluate the correlation between RDW, MLR and platelet parameters and the prognosis of chronic HBV infection related liver disease.Results: The levels of ALT, AST, TBIL, HBeAg, RDW, MLR, PDW and MPV were higher in HBV-LC group and CHB group than those in control group(P<0.05), the levels of ALB, PLT and PCT were lower than those in control group(P<0.05). The indexes of HBV-LC group were better than those of CHB group(P<0.05). RDW, MLR and MPV were positively correlated with ALT and AST, negatively correlated with ALB, MLR positively correlated with TBIL, PLT and PCT were positively correlated with ALT, AST, TBIL, and negatively correlated with ALB. LSM was positively correlated with RDW, MLR and MPV, and negatively correlated with PLT and PCT. The levels of RDW, MLR, PDW and MPV were higher in the poor prognosis group than those in the good prognosis group(P<0.05), while the PLT and PCT levels were lower in the poor prognosis group than those in the good prognosis group.Conclusion: RDW, MLR and platelet parameters may be effective indicators to evaluate the severity and prognosis of chronic HBV infection related liver disease, which may be worthy of promotion and application.
- hepatitis B virus /
- liver disease /
- red blood cell distribution width /
- monocyte/lymphocyte ratio /
- platelet parameters

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