Effect of reducing preventive platelet transfusion dose on patients with thrombocytopenia after chemotherapy
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摘要: 目的：探讨降低预防性血小板输注剂量应用于化疗后血小板减少症患者的效果。方法：选择2018年10月—2019年10月收治的化疗后血小板减少症患者96例，按随机数字表法分为2组，各48例。对照组接受标准剂量预防性血小板输注，观察组接受低剂量预防性血小板输注。对比2组血小板输注相关指标、输血后出血情况及不良反应发生率。结果：观察组输血后血小板计数、平均血小板输注总量低于对照组（P<0.05）；观察组前后2次输血间隔时间短于对照组（P<0.05）；观察组平均每例患者血小板输注次数高于对照组（P<0.05）；观察组至少出现1次2级以上出血、2级、3级、4级出血发生率与对照组比较，差异无统计学意义（P>0.05）；观察组输血后不良反应发生率与对照组比较，差异无统计学意义（P>0.05）。结论：低剂量预防性血小板输注应用于化疗后血小板减少症患者可减少血小板输注总量，保障输血安全，值得推广。Abstract: Objective: To investigate the effect of reducing the preventive platelet transfusion dose on patients with thrombocytopenia after chemotherapy.Methods: A total of 96 patients with chemotherapy-induced thrombocytopenia treated in our hospital from October 2018 to October 2019 were selected and divided into two groups according to the random number table method, 48 cases each. The control group received standard dose preventive platelet transfusion, and the observation group received low dose preventive platelet transfusion. The indexes related to platelet transfusion, bleeding after transfusion, and the incidence of adverse reactions were compared between the two groups.Results: The platelet count and average platelet transfusion volume in the observation group were lower than those in the control group(P<0.05). The interval between the two blood transfusions in the observation group was shorter than that in the control group(P<0.05); the average number of platelet transfusions per patient in the observation group was higher than that in the control group(P<0.05); at least one grade 2 or higher bleeding, grade 2, 3, or 4 bleeding occurred in the observation group compared with the control group, the incidence was not statistically significant(P>0.05); the incidence of adverse reactions after blood transfusion in the observation group was not statistically significant compared with the control group(P>0.05).Conclusion: The use of low-dose prophylactic platelet transfusion in patients with thrombocytopenia after chemotherapy can reduce the total number of platelet transfusions, ensure the safety of blood transfusion, and may be worth promoting.
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Key words:
- preventive platelet transfusion /
- low dose /
- chronic thrombocytopenia /
- bleeding /
- adverse reactions
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