XG血型抗原研究进展

史华山; 李树中; 李中华; 李凌波; 田丰

doi:10.13201/j.issn.1004-2806.2021.10.015

XG血型抗原研究进展

- 1. 磁县人民医院输血科(河北磁县, 056500);
- 2. 江苏大学附属昆山医院;
- 3. 黑龙江省牡丹江市第二人民医院;
- 4. 长春博迅生物技术有限责任公司;
- 5. 江苏省昆山市第三人民医院

详细信息

通讯作者: 李树中,E-mail:kssyylsz@sina.cn

中图分类号: R457.1

收稿日期: 2020-03-02

Research progress of XG blood group antigen

More Information

Corresponding author: LI Shuzhong, E-mail: kssyylsz@sina.cn

Received Date: 02 March 2020

摘要

- MIC2/XG基因 /
- XG糖蛋白 /
- 膜分化抗原 /
- 免疫黏附因子 /
- 肿瘤标志物
Abstract: XG blood group antigen is an erythrocyte antigen with special genetic significance.The genes of XG blood group antigen are two closely linked and independent genes.This paper introduces the detailed information of gene exon sequence,length and coding of each coding segment,coding translation product sequence and so on.The hereditary characteristics of antigen genes on X and Y chromosomes are briefly described in detail.XG blood group antigen gene is a unique gene.The in-depth study of this gene has overturned the Leon theory of genetics in the past and has important genetic significance.XG2 antigen is a membrane differentiation antigen CD99,which participates in the erythrocyte immune mechanism and is one of the markers of cancer,and has important clinical significance.XG antigen generally does not cause transfusion hemolytic reaction and neonatal hemolytic disease,but it can interfere with clinical blood transfusion test and cause confusion of blood transfusion.
- MIC2/XG gene /
- XG glycoprotein /
- membrane differentiation antigen /
- immune adhesion factor /
- tumor markers

HTML全文

参考文献(28)

[1]	Geoff Daniels.Human Blood Groups[M].3nd.edition, 2002:359-370.
[2]	Marion E.The Blood Group Antigen[M].FactsBook, 2012:421-426.
[3]	Möller M, Lee YQ, Vidovic K, et al.Disruption of a GATA1-binding motif upstream of XG/PBDX abolishes Xga expression and resolves the Xg blood group system[J].Blood, 2018, 132(3):334-338.
[4]	Lane WJ, Aguad M, Smeland-Wagman R, et al.A whole genome approach for discovering the genetic basis of blood group antigens:independent confirmation for P1 and Xga[J].Transfusion, 2019, 59(3):908-915.
[5]	Yeh CC, Chang CJ, Twu YC, et al.The molecular genetic background leading to the formation of the human erythroid-specific Xga/CD99 blood groups[J].Blood Adv, 2018, 2(15):1854-1864.
[6]	Zimmerman PA.XG blood group puzzle solved:what's next?[J].Blood, 2018, 132(3):243.
[7]	Khurana S, Coffey MJ, John A, et al.Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection[J].J Biol Chem, 2019, 294(5):1541-1553.
[8]	Thangaretnam KP, Paramasivam OR, Ramanathan P, et al.Production and characterization of monoclonal antibodies against recombinant extracellular domain of CD99[J].Hum Antibodies, 2019, 27(1):69-83.
[9]	Gras S, Jackson A, Woods S, et al.Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo[J].Wellcome Open Res, 2017, 2:32.
[10]	Chung SS, Eng WS, Hu W, et al.CD99 is a therapeutic target on disease stem cells in myeloid malignancies[J].Sci Transl Med, 2017, 9(374):eaaj2025.
[11]	Zhou G, Yang W, Yu L, et al.CD99 refers to the activity of inflammatory bowel disease[J].Scand J Gastroenterol.2017, 52(3):359-364.
[12]	Martinelli M, Parra A, Scapoli L, et al.CD99 polymorphisms significantly influence the probability to develop Ewing sarcoma in earlier age and patient disease progression[J].Oncotarget, 2016, 7(47):77958-77967.
[13]	Mahiddine K, Mallavialle A, Bziouech H, et al.CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2/CREB-1 phosphorylation[J].Eur J Immunol, 2016, 46(6):1460-1471.
[14]	Enein AA, Rahman HA, Sharkawy NE, et al.Significance of CD99 expression in T-lineage acute lymphoblastic leukemia[J].Cancer Biomark, 2016, 17(2):117-123.
[15]	Domínguez-Malagón HR, Michal M, Kazakov DV, et al.Utility of CD99 Paranuclear Expression in the Differential Diagnosis of Merkel Cell Carcinoma[J].Int J Surg Pathol, 2016, 24(4):293-296.
[16]	Ventura S, Aryee DN, Felicetti F, et al.CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling[J].Oncogene, 2016, 35(30):3944-3954.
[17]	Gil M, Pak HK, Lee AN, et al.CD99 regulates CXCL12-induced chemotaxis of human plasma cells[J].Immunol Lett 2015, 168(2):329-336.
[18]	Jian W, Zhong L, Wen J, et al.SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma[J].PLoS One, 2015, 10(5):e0127568.
[19]	Oranger A, Brunetti G, Carbone C, et al.Human myeloma cell lines induce osteoblast downregulation of CD99 which is involved in osteoblast formation and activity[J].J Immunol Res, 2015:156787.
[20]	Guerzoni C, Fiori V, Terracciano M, et al.CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin[J].Clin Cancer Res, 2015, 21(1):146-156.
[21]	张志琴, 李中华, 张黎雯.Duffy血型抗原的G-蛋白偶联受体作用[J].临床血液学杂志, 2019, 32(2):162-166.
[22]	徐姿, 李中华, 李凌波.Junier抗原的最新研究进展[J].临床血液学杂志, 2019, 32(4):322-326.
[23]	王鹤, 李中华, 李凌波.RHAG血型抗原研究进展[J].临床血液学杂志, 2019, 32(6):479-482.
[24]	叶小英, 李中华, 李凌波, 等.CD59-血型抗原的研究新进展[J].临床血液学杂志, 2019, 32(6):487-489.
[25]	高汉超, 张汉成, 高奇, 等.猪抗原和对应抗体在异种移植中的研究进展[J].医学综述, 2017, 23(5):833-837, 842.
[26]	胡氏月, 李中华, 吴建红, 等.Globoside血型抗原研究进展[J].临床血液学杂志, 2019, 32(10):813-817.
[27]	叶小英, 田丰, 李树中.红细胞血型I抗原研究进展[J].临床血液学杂志, 2019, 32(12):982-988.
[28]	卞洁.红细胞血型RAPH抗原研究进展[J].临床血液学杂志, 2020, 33(2):148-150.