红细胞Diego血型抗原研究进展

谢怡萍; 李树中; 李中华; 李凌波; 田丰

doi:10.13201/j.issn.1004-2806.2021.10.016

红细胞Diego血型抗原研究进展

- 1. 江苏大学附属昆山医院(江苏昆山, 215300);
- 2. 黑龙江省牡丹江市第二人民医院;
- 3. 长春博讯生物技术有限责任公司;
- 4. 江苏省昆山市第三人民医院

详细信息

通讯作者: 李树中,E-mail:kssyylsz@sina.cn

中图分类号: R457.1

收稿日期: 2020-06-06

Research progress of erythrocyte Diego blood group antigen

More Information

Corresponding author: LI Shuzhong, E-mail: kssyylsz@sina.cn

Received Date: 06 June 2020

摘要

- 溶质载体转运蛋白 /
- 带3蛋白 /
- CD233 /
- 东南亚卵形红细胞血症 /
- 输血性溶血
Abstract: Di aantigen is anthropologically related to the Mongolian race.The antigen gene is composed of 20 exons,and the translation product is Di glycoprotein/solute carrier transporter(SLC4 A1),also known as cell membrane band 3 protein(EPB-3),or“anion transporter”(AEI-7),also CD233.Di glycoprotein peptide chain passes through the cell membrane 14 times,leaving 7 loops outside the membrane.All Di system antigens are expressed on the outer membrane loop.Band 3 protein is one of the main components of erythrocyte membrane and skeleton.The lack of band 3 protein will lead to the collapse of red blood cells,which is clinically manifested as oval erythrocythemia in Southeast Asia.Di antigen can cause transfusion hemolysis and neonatal hemolytic disease,and is a clinically important blood group antigen.
- solute carrier transporter /
- band 3protein /
- CD233 /
- southeast asian oval erythrocythemia /
- transfu-sion hemolysis

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