红细胞血型CH/RG抗原研究进展

朱丽娟; 李树中; 李中华; 田丰

doi:10.13201/j.issn.1004-2806.2021.12.017

红细胞血型CH/RG抗原研究进展

- 1. 江苏大学附属昆山医院(江苏昆山, 215300);
- 2. 牡丹江市第二人民医院;
- 3. 昆山市第三人民医院

详细信息

通讯作者: 李树中,E-mail:kssyylsz@sina.cn

中图分类号: R457.1

收稿日期: 2020-07-06

Advances in research of erythrocyte blood group CH/RG antigen

More Information

Corresponding author: LI Shuzhong, E-mail: kssyylsz@sina.cn

Received Date: 06 July 2020

摘要

摘要: CH/RG抗原是目前39个血型系统中唯一连接在细胞膜唾液酸上的Ⅴ型跨膜蛋白抗原，也是研究和报道比较少的红细胞血型抗原。近几年来国外对此抗原的研究有了较多的新进展，本文就CH/RG抗原的一些国内外报道，做一简要综述。1血型遗传学CH/RG抗原的基因位点在6号染色体；6p21.33；基因名"RG/CH "，是由2组基因组成：" RG/C4A "和" CH/C4B"；2个基因位点紧密相连，高度相似，99%都同源，
- C4A/C4B基因 /
- 染色体不等交换 /
- 补体C4A/C4B糖蛋白 /
- Ⅴ型跨膜蛋白
Abstract: CH/RG antigen is an antigen linked in sialic acid on the cell membrane, and is the only type Ⅴ transmembrane protein antigen in the 39 blood type system. The unequal exchange of homologous chromosome, can cause C4 A/C4 B to be deleted on one chromosome, and multiply on another chromosome, and express as some C4 gene duplication, while some C4 gene deletion(C4 null gene). This kind of chromosome unequal exchange have higher frequency in CH/RG blood group gene. CH/RG antigens generally do not cause transfusion hemolytic reactions and HDNF.
- C4A/C4B genes /
- chromosome inequality in communication /
- C4A/C4B glycoprotein supplementation /
- Ⅴ transmembrane protein

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