Splenic abscess as the first manifestation of chronic neutrophilic leukemia: a case report
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关键词:
- 慢性中性粒细胞白血病 /
- 不典型慢性粒细胞白血病 /
- CSF3R突变 /
- 脾脓肿
Abstract: To improve the diagnosis and therapy of chronic neutrophilic leukemia(CNL), we reviewed the hematological and clinical characteristics of a patient with CNL. The onset of disease showed splenomegaly and splenic abscess. Peripheral white blood cell count went up obviously and then transiently decreased as disease progression, followed by anemia, thrombocytopenia, myelofibrosis and CSF3R mutation. The patient was first misdiagnosed as atypical chronic myeloid leukemia, and then diagnosed as CNL by MICM reassessment. Splenctomy was performed but hemoglobin level and platelet count had not been improved significantly, and allogeneic hematopoietic stem cell transplantation is planned. CNL is a rare hematological disease with high clinical heterogeneity, and splenic abscess as the first manifestation has not been reported. -
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