血细胞各比值对慢性丙型肝炎病毒患者肝纤维化程度的评估

邵林楠; 张树婷; 王霓; 周世航; 刘铭

doi:10.13201/j.issn.1004-2806.2022.12.008

血细胞各比值对慢性丙型肝炎病毒患者肝纤维化程度的评估

- 1.
  大连市血液中心(辽宁大连，116001)
- 2.
  大连医科大学，细胞生物学教研室
基金项目:
大连市青年科技之星(No: 2017RQ170)

详细信息

通讯作者: 刘铭，E-mail：liuminglinxi@163.com

中图分类号: R512.6

收稿日期: 2022-08-02

修回日期: 2022-09-28

刊出日期: 2022-12-01

Evaluation of PLR, NLR and LMR on hepatic fibrosis in chronic HCV patients

- 1.
  Dalian Blood Center, Dalian, 116001, China
- 2.
  Department of Cell Biology, Dalian Medical University

More Information

Corresponding author: LIU Ming, E-mail: liuminglinxi@163.com

Received Date: 02 August 2022

Revised Date: 28 September 2022

Publish Date: 01 December 2022

摘要

摘要: 目的分析探究在慢性丙型肝炎病毒(HCV)患者血细胞中血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)和肝纤维化严重程度的关联。方法随机选取慢性HCV患者210例，检测血常规、肝纤维化指标数据，通过相关性分析及对患者按照肝纤维化指标高低分组比较的方法研究PLR、NLR及LMR与肝纤维化的关系。结果相关性分析结果显示，PLR与透明质酸(HA)、Ⅲ型氨基末端前肽胶原蛋白(PIIINP)、层黏连蛋白(LN)、胶原Ⅳ(C-IV)、谷草转氨酶与血小板比值指数(APRI)和纤维化4评分(FIB-4)等肝纤维化指标均呈负相关；NLR只与LN和APRI成弱相关性；LMR与上述肝纤维化指标均不相关。分组比较高纤维化指标患者的PLR显著降低(P＜0.05)，NLR及LMR在肝纤维化指标的高低分组中差异均无统计学意义。结论在慢性HCV感染患者中，PLR与患者肝纤维化存在显著相关性，本研究为临床评估肝纤维化的进展提供了简便、有效的观测指标。
- 慢性丙型肝炎病毒 /
- 肝纤维化 /
- 血小板/淋巴细胞比值 /
- 中性粒细胞/淋巴细胞比值 /
- 淋巴细胞/单核细胞比值
Abstract: ObjectiveTo analyze the association between platelet lymphocyte ratio(PLR), neutrophil lymphocyte ratio(NLR), lymphocyte monocyte ratio(LMR) and liver fibrosis in chronic HCV patients.MethodsA total of 210 cases patients with chronic HCV infection in Dalian were studied. Blood routine examination data and liver fibrosis related parameters were collected. The association between PLR, NLR, LMR and liver fibrosis were studied by correlation analysis and comparing the PLR, NLR and LMR in different groups according to the liver fibrosis indices.ResultsPLR was negatively correlated with LN, HA, PIIINP, C-IV, APRI and FIB-4; NLR was only weakly correlated with LN and APRI; LMR was not correlated with the liver fibrosis indices. Further grouping comparison showed that PLR decreased significantly in high fibrosis indices group and there was no significant differences of NLR and LMR between two groups.ConclusionIn patients with chronic HCV infection, PLR was a useful index to predict the degree of liver fibrosis.
- hepatitis C virus /
- hepatic fibrosis /
- platelet lymphocyte ratio /
- neutrophil lymphocyte ratio /
- lymphocyte monocyte ratio

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图 1 慢性HCV患者PLR、NLR、LMR与肝纤维化指标间的相关性分析

下载: 全尺寸图片幻灯片

表 1 慢性HCV患者PLR、NLR、LMR在高低纤维化指标分组间比较 M(P₂₅，P₇₅)

	指标	PLR	NLR	LMR
C-Ⅳ	≤100 μg/L	103.05(79.01，130.97)	1.44(1.05，1.89)	8.83(6.70，11.67)
	＞100 μg/L	70.75(47.88，90.09)	1.32(0.95，1.64)	8.32(6.57，13.41)
LN	≤100 μg/L	97.42(75.42，123.43)	1.44(1.11，1.85)	8.53(6.70，11.90)
	＞100 μg/L	72.00(47.88，98.22)	1.24(0.93，1.74)	8.63(6.40，13.29)
PⅢNP	≤10 μg/L	98.91(77.83，123.95)	1.40(1.09，1.80)	8.51(6.73，11.67)
	＞10 μg/L	70.15(44.53，89.93)	1.29(0.91，1.91)	8.99(6.39，13.37)
HA	≤100 μg/L	101.25(72.19，126.03)	1.42(1.09，1.89)	8.81(6.89，12.09)
	＞100 μg/L	81.48(58.56，109.70)	1.32(0.96，1.77)	8.19(6.50，11.95)
APRI	≤1	106.06(80.58，132.14)	1.45(1.12，1.79)	9.16(6.73，12.30)
	＞1	80.12(54.84，104.84)	1.31(0.94，1.87)	8.19(6.62，11.58)
FIB-4	≤2	108.50(87.47，138.57)	1.45(1.12，1.79)	8.67(6.72，12.21)
	＞2	79.27(55.23，102.11)	1.32(0.95，1.85)	8.41(6.62，11.70)

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