Primary osseous Hodgkin's lymphoma originating from cervical spine: a case report and literature review
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摘要: 原发性骨霍奇金淋巴瘤(POHL)极为罕见，被定义为一种病变局限于骨骼或邻近软组织的恶性肿瘤，在确诊后6个月内没有任何区域上淋巴结或其他淋巴结外器官受累的证据。文章报告1例原发于颈椎的患者，通过临床表现、影像学、组织病理学和免疫组织化学，最终诊断为POHL，患者接受颈椎后路椎板切除术减压、肿瘤切除、ABVD化疗，但因病情加重死亡。POHL的整体患者较少，具体预后尚不清楚，可能与病变部位及范围、年龄等因素有关，应提高对起源于颈椎POHL的认识。
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关键词:
- 颈椎 /
- 原发性骨霍奇金淋巴瘤 /
- 影像学 /
- 组织病理学 /
- 免疫组织化学
Abstract: Primary osseous Hodgkin's lymphoma(POHL) was defined as a malignancy with lesions confined to bone or adjacent soft tissue, there was no evidence of involvement of any supramolecular lymph nodes or other extrinsic lymph nodes within 6 months after diagnosis. We reported a case that originated from the cervical vertebra, after the diagnosis of clinical manifestations, imaging, histopathology and immunohistochemistry, the patient was finally diagnosed with POHL, the patient was treated with posterior cervical laminectomy decompression, tumor resection, and ABVD chemotherapy, but she died of exacerbation. The overall cases of POHL are few, and the specific prognosis of POHL is unknown, which may be related to the lesion site and scope, age and other factors. we should improve the knowledge of POHL originating from cervical spine.-
Key words:
- cervical spine /
- primary osseous Hodgkin's lymphoma /
- imaging /
- histopathology /
- immunohistochemistry
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表 1 报道的POHL患者汇总
作者 发病时间 发病年龄/岁 部位 随访 参考文献 Ostrowski 1927 42 胸椎 无病生存 [4] Ostrowski 1958 53 肱骨、髂骨 死亡 [4] Ostrowski 1968 34 肱骨 无病生存 [4] Gold 1979 25 肱骨 无病生存 [5] Chan 1982 12 股骨 无病生存 [6] Moridaira 1994 56 胸椎 完全缓解 [7] Ostrowski 1995 61 胸椎 无病生存 [4] Eustace 1995 63 肱骨、髂骨 无病生存 [8] Citow 2001 54 胸椎 无病生存 [9] Gebert 2005 21 股骨、胫骨 无病生存 [10] Caavi 2006 39 颈椎、腰椎 肿块消失 [11] Rabhi 2007 54 胸椎 反应良好 [12] Langley 2008 7 胸骨、腰椎 症状减轻 [13] Oshikawa 2009 28 胸骨、髂骨、肋骨、肩胛骨 完全缓解 [14] Breibach 2009 17 骶骨 完全缓解 [15] Binesh 2012 63 腰椎 完全缓解 [1] Geramizadeh 2012 24 肩胛骨 无病生存 [16] Kasper 2012 88 胸椎 死亡 [17] Li 2012 38 肋骨 无病生存 [1] Kamezaki 2012 66 肋骨、多锥体、肩胛骨、骨盆、股骨 完全缓解 [18] Ha-ou-nou 2013 35 髂骨、骶骨 症状消失 [3] Uehara 2013 28 胸椎 无病生存 [19] Luo 2015 22 腰椎、骶髂关节、肩胛骨 复发 [20] Jain 2016 30 胸骨 完全缓解 [21] Fourati 2017 24 骶骨 完全缓解 [22] Tang 2017 20 骨盆 无病生存 [2] Yin 2020 47 胸骨 完全缓解 [23] Siddiqui 2021 7 髋骨 无病生存 [24] Virk 2021 36 股骨 无病生存 [25] Alkendi 2021 13 胸骨、髂骨骶骨、脊柱 完全缓解 [26] 
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[1] Binesh F, Mirjalili MR, Akhavan A, et al. Primary bony Hodgkin's lymphoma[J]. BMJ Case Rep, 2012, 2012: bcr0120125714.
[2] Tang F, Min L, Ye Y, et al. Classic Hodgkin lymphoma in pelvis: A case report highlights diagnosis and treatment challenges[J]. Medicine(Baltimore), 2017, 96(39): e8196.
[3] Ha-ou-nou FZ, Benjilali L, Essaadouni L. Sacral pain as the initial symptom in primary Hodgkin's lymphoma of bone[J]. J Cancer Res Ther, 2013: 9(3): 511-513. doi: 10.4103/0973-1482.119365
[4] Ostrowski ML, Inwards CY, Strickler JG, et al. Osseous Hodgkin disease[J]. Cancer, 1999, 85(5): 1166-1178. doi: 10.1002/(SICI)1097-0142(19990301)85:5<1166::AID-CNCR22>3.0.CO;2-V
[5] Gold RH, Mirra JM. Case report 101. Primary Hodgkin disease of humerus[J]. Skeletal Radiol, 1979, 4(4): 233-235. doi: 10.1007/BF00347220
[6] Chan KW, Rosen G, Miller DR, et al. Hodgkin's diseases in adolescents presenting as a primary bone lesion. A report of four cases and review of literature[J]. Am J Pediatr Hematol Oncol, 1982, 4(1): 11-17.
[7] Moridaira K, Handa H, Murakami H, et al. Primary Hodgkin's disease of the bone presenting with an extradural tumor[J]. Acta Haematol, 1994, 92(3): 148-149. doi: 10.1159/000204207
[8] Eustace S, O'Regan R, Graham D, et al. Primary multifocal skeletal Hodgkin's disease confined to bone[J]. Skeletal Radiol, 1995, 24(1): 61-63. doi: 10.1007/BF02425953
[9] Citow JS, Rini B, Wollmann R, et al. Isolated, primary extranodal Hodgkin's disease of the spine: case report[J]. Neurosurgery, 2001, 49(2): 453-456, 456-457.
[10] Gebert C, Hardes J, Ahrens H, et al. Primary multifocal osseous Hodgkin disease: a case report and review of the literature[J]. J Cancer Res Clin Oncol, 2005, 131(3): 163-168. doi: 10.1007/s00432-004-0641-0
[11] Caǧavi F, Kalayci M, Tekin IO, et al. Primary spinal extranodal Hodgkin's disease at two levels[J]. Clin Neurol Neurosurg, 2006, 108(2): 168-173. doi: 10.1016/j.clineuro.2004.11.023
[12] Rabhi M, Ennibi K, Chaari J, et al. Hodgkin's disease presenting with spinal cord compression[J]. Rev Neurol(Paris), 2007, 163(11): 1109-1112. doi: 10.1016/S0035-3787(07)74187-5
[13] Langley CR, Garrett SJ, Urand J, et al. Primary multifocal osseous Hodgkin's lymphoma[J]. World J Surg Oncol, 2008, 6: 34. doi: 10.1186/1477-7819-6-34
[14] Oshikawa G, Arai A, Sasaki K, et al. Primary multifocal osseous Hodgkin lymphoma[J]. Rinsho Ketsueki, 2009, 50(2): 92-96.
[15] Breibach F, Julian A, Laurent C, et al. Contribution of the 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography to the diagnosis of primary osseous Hodgkin lymphoma[J]. BMJ Case Rep, 2009, 2009.
[16] Geramizadeh B, Farzaneh M, Ramzi M, et al. Primary Solitary Osseous Hodgkin's Lymphoma: A Case Report and Review of the Literature[J]. Iran Red Crescent Med J, 2012, 14(5): 313-315.
[17] Kasper EM, Lam FC, Luedi MM, et al. Primary epidural lymphocyte-depleted Hodgkin's lymphoma of the thoracic spine-presentation of a rare disease variant[J]. BMC Neurol, 2012, 12: 64. doi: 10.1186/1471-2377-12-64
[18] Kamezaki K, Harada Y, Shimono N, et al. Diagnostic usefulness of FDG-PET/CT in multiple primary osseous Hodgkin lymphoma[J]. Rinsho Ketsueki, 2012, 53(12): 2003-2007.
[19] Uehara M, Takahashi J, Hirabayashi H, et al. Hodgkin's disease of the thoracic vertebrae[J]. Spine J, 2013, 13(8): e59-e63. doi: 10.1016/j.spinee.2013.03.026
[20] Luo W, Zhang F, Sun J, et al. Unusual primary osseous Hodgkin's lymphoma: A case report[J]. Oncol Lett, 2015, 9(2): 677-680. doi: 10.3892/ol.2014.2724
[21] Jain A, Gupta N. Primary Hodgkin's Lymphoma of the Sternum: Report of a Case and Review of the Literature[J]. J Clin Diagn Res, 2016, 10(6): XE07-XE10.
[22] Fourati N, Kanoun BS, Regaieg H, et al. Primary osseous Hodgkin's lymphoma of the sacrum: A diagnostic and therapeutic challenge[J]. Cancer Radiother, 2017, 21(1): 51-54. doi: 10.1016/j.canrad.2016.09.013
[23] Yin YY, Zhao N, Yang B, et al. Sternal Hodgkin's lymphoma: A case report and review of literature[J]. World J Clin Cases, 2020, 8(3): 638-644. doi: 10.12998/wjcc.v8.i3.638
[24] Siddiqui DE, Akbar HF, Sadiq H, et al. Primary Hodgkin's Lymphoma of bone in 7-year-old-an exceptional case report of youngest child in literature[J]. Cancer Treat Res Commun, 2021, 29: 100448. doi: 10.1016/j.ctarc.2021.100448
[25] Virk JS, Bhaker P, Singh P, et al. Extremely rare case of primary nodular lymphocyte-predominant Hodgkin's lymphoma of distal femur[J]. BMJ Case Rep, 2021, 14(2): e240903. doi: 10.1136/bcr-2020-240903
[26] Alkendi J, Renzi S, Manson D, et al. Hodgkin's Lymphoma in an Adolescent With Isolated Bone Marrow and Bone Involvement: A Case Report and a Review of the Literature[J]. J Pediatr Hematol Oncol, 2021, 43(1): e115-e118. doi: 10.1097/MPH.0000000000001580
[27] Li Y, Wang XB, Tian XY, et al. Unusual primary osseous Hodgkin lymphoma in rib with associated soft tissue mass: a case report and review of literature[J]. Diagn Pathol, 2012, 7: 64. doi: 10.1186/1746-1596-7-64
[28] McCarten KM, Nadel HR, Shulkin BL, et al. Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma[J]. Pediatr Radiol, 2019, 49(11): 1545-1564. doi: 10.1007/s00247-019-04529-8
[29] Smith ZA, Sedrak MF, Khoo LT. Primary bony non-Hodgkin lymphoma of the cervical spine: a case report[J]. J Med Case Rep, 2010, 4: 35. doi: 10.1186/1752-1947-4-35
[30] Mengiardi B, Honegger H, Hodler J, et al. Primary lymphoma of bone: MRI and CT characteristics during and after successful treatment[J]. AJR Am J Roentgenol, 2005, 184(1): 185-192. doi: 10.2214/ajr.184.1.01840185
[31] 李潇, 张慕晨, 钱樱, 等. 151例纵隔肿块起病的淋巴瘤临床特征以及预后分析[J]. 临床血液学杂志, 2021, 34(11): 765-770. doi: 10.13201/j.issn.1004-2806.2021.11.004
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