血浆凝血因子ⅩⅢ、IL-17水平与脑梗死相关性及预后的研究

韦深; 唐万兵; 李梅笑; 李观强; 武胜; 万彦彬; 蔡洁丹

血浆凝血因子ⅩⅢ、IL-17水平与脑梗死相关性及预后的研究

- 1. 深圳市龙岗区人民医院检验科(广东深圳, 518172);
- 2. 深圳市龙岗区人民医院神经内科;
- 3. 深圳市龙岗区人民医院影像科
基金项目:
深圳市科技计划项目（No：201103248）

详细信息

通讯作者: 唐万兵,E-mail:tangwanbing453@163.com

中图分类号: R743.33

收稿日期: 2013-03-25

Research on correlation and prognosis of plasma coagulation factor ⅩⅢ and IL-17 levels in patients with cerebral infarction

- 1. Department of Laboratory, Longgang District People's Hospital of Shenzhen, Shenzhen, 518172, China;
- 2. Department of Neurology, Longgang District People's Hospital of Shenzhen;
- 3. Department of Radiology, Longgang District People's Hospital of Shenzhen

More Information

Corresponding author: TANG Wanbing, E-mail: tangwanbing453@163.com

Received Date: 25 March 2013

摘要

摘要: 目的：探讨血浆凝血因子ⅩⅢ（FⅩⅢ）、IL-17水平与脑梗死患者病程进展及预后的相关性。方法：①对50例脑梗死患者根据头部CT或MRI病灶大小，梗死体积按Pullicino公式（长×宽×层数/2）计算进行分组：大梗死组（病灶体积>10 cm³），中梗死组（病灶体积4~10 cm³），小梗死组（病灶体积<4 cm³）；健康对照组20例，神经功能受损程度按照NIHSS进行评分。分别在24 h内、第3天、第7天、第14天采集脑梗死组抗凝血标本。采用酶联免疫双抗体夹心法检测FⅩⅢ、IL-17含量。②根据脑梗死组发病24 h内和第14天的NIHSS评分进行近期预后分型比较。结果：①大梗死组发病24 h内FⅩⅢ、IL-17水平明显高于对照组（P<0.01），中、小梗死组发病24 h内FⅩⅢ、IL-17水平高于对照组（P<0.05）。②大梗死组FⅩⅢ、IL-17水平与小梗死组比较差异有统计学意义（P<0.05）。③随着梗死病情好转，FⅩⅢ、IL-17水平有下降趋势（P>0.05）。④脑梗死组患者近期预后与FⅩⅢ水平下降呈正相关（r=0.33），与IL-17水平下降呈正相关（r=0.31）。结论：脑梗死患者血浆FⅩⅢ、IL-17水平与病程及预后呈正相关，其水平变化可作为脑梗死治疗及预后的判断指标。
- 脑梗死 /
- 凝血因子ⅩⅢ /
- IL-17 /
- 预后 /
- 相关性
Abstract: Objective: To discuss the correlation and prognosis on the levels of plasma coagulation factor ⅩⅢ(FⅩⅢ) and IL-17 in patients with cerebral infarction.Method: ①According to the infarction size of CT or MRI of head,50 patients with cerebral infarction were divided into three groups:great dimension infarction group (infarction size>10 cm³),middle dimension infarction group (infarction size 4 to 10 cm³) and small dimension infarction group (infarction size<4 cm³).Healthy control group included 20 cases.Damage degree of nerve function was evaluated according to NIHSS score.Anticoagulant specimens of cerebral infarction group were collected within 24 h,at 3rd day,7th day and 14th day respectively.The levels of FⅩⅢ and IL-17 were measured by enzyme linked immune double antibody sandwich assay.②According to NIHSS scores within 24 h and 14th day of cerebral infarction group,recent prognosis was compared.Result: ①The levels of FⅩⅢ and IL-17 of great dimension infarction group within 24 h were obviously higher than those of control group (P<0.01),the levels of FⅩⅢ and IL-17 of middle dimension infarction group and small dimension infarction group within 24 h were higher than those of control group (P<0.05).②Compared with small dimension infarction group,the levels of FⅩⅢ and IL-17 of great dimension infarction group were different (P<0.05).③Along with the state of illness improved,the levels of FⅩⅢ and IL-17 had decline tendency (P>0.05).④The level of FⅩⅢ was positively correlated with the recent prognosis in patients with cerebral infarction groups (r=0.33),the level of IL-17 was positively correlated (r=0.31).Conclusion: The levels of FⅩⅢ and IL-17 in patients with cerebral infarction would have positive correlation with course and prognosis,and their changes could be used as diagnose indexes of treatment and prognosis.
- cerebral infarction /
- FⅩⅢ /
- IL-17 /
- prognosis /
- correlation

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