-
摘要: 目的:评估临床接受治疗的非透析的慢性肾脏病(CKD)患者心血管病(CVD)系列危险因素,为临床早期预防和治疗提供理论依据。方法:选择196例非透析CKD患者并根据肾小球滤过率(GRF)进行分期,同时选择30例健康人作为对照。根据身高、体重计算BMI,同时采血测定TC、TG、HDL-C、LDL-C、ALB、Hb、RBC、WBC、hs-CRP,留取 24 h尿液并测定尿总蛋白。结果:TC、TG及LDL-C水平在CKD 1~2期呈上升趋势,自CKD 3期开始下降。HDL-C从CKD 1期开始呈现下降趋势,CKD 4~5期HDL-C较对照组显著降低(P<0.05)。CKD各期WBC无显著变化,hs-CRP在CKD各期均呈逐渐升高趋势,CKD 3期开始较对照组显著升高(P<0.01)。CKD各期ALB、Hb、RBC较对照组均显著降低(P<0.05)。CKD患者中 24 h尿蛋白较对照组均显著升高,其中CKD 3期最高,显著高于CKD 1~2期和CKD 4~5期。结论:慢性非透析肾脏病住院患者多个心血管病危险因素均呈现高危变化,且随CKD分期而不同。因此,评估CKD患者CVD危险因素能为临床治疗决策提供依据。
-
-
[1] WEINER D E.Public health consequences of chronic kidney disease[J].Clin Pharmacol Ther,2009,86:566-569.
[2] Centers for disease control and prevention(CDC).State-specific trends in chronic kidney failure,United States,1990-2001[J].MMWR Morb Mortal Wkly Rep,2004,53:918-920.
[3] PETER A M,SUSAN S,KIRIT T,et al.Cardiovascular disease in chronic kidney disease:data from the kidney early evaluation program(KEEP)[J].Curr Diab Rep,2011,11:47-55.
[4] DANIEL E W,HOCINE T,MANISH G A,et al.Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality:a pooled analysis of community-based studies[J].J Am Soc Nephrol,2004,15:1307-1315.
[5] 杨晓,苏华.慢性肾脏病患者心血管疾病危险因素分析[J].医学新知杂志,2011,21(3):168-171.
[6] CHARLES R H,TERRY A J.Managing dyslipidemia in chronic kidney disease[J].J Am Coll Cardiol,2008,51:2375-2384.
[7] SULIMAN M E,STENVINKEL P.Contribution of inflammation to vascular disease in chronic kidney disease patients[J].Saudi J Kidney Dis Transpl,2008,19:329-345.
[8] FOUQUE D,APARICIO M.Eleven reasons to control the protein intake of patients with chronic kidney disease[J].Nat Clin Pract Nephrol,2007,3:383-392.
[9] 高翔,梅长林.蛋白尿引起慢性肾脏病肾小球损伤的机制及治疗[J].中华肾脏病杂志,2008,24(3):210-213.
[10] IRIE F,ISO H,SAIRENCHI T,et al.The relationships of proteinuria,serum creatinina,glomerular filtration rate with cardiovascular disease mortality in Japanese general population[J].Kindey Int,2006,69:1264-1271.
-
计量
- 文章访问数: 36
- PDF下载数: 180
- 施引文献: 0
下载: