血浆置换治疗重型乙型病毒性肝炎血清病毒载量变化及疗效观察

饶绘; 臧莉

血浆置换治疗重型乙型病毒性肝炎血清病毒载量变化及疗效观察

饶绘^1, ,,
臧莉²

- 1. 襄阳市中心医院检验科(湖北襄阳, 441021);
- 2. 襄阳市中心医院肾内科

详细信息

通讯作者: 饶绘,E-mail:raohui2004@sina.com

中图分类号: R512.6

收稿日期: 2012-10-10

Changes of serum HBV-DNA loads and prognosis observation after plasma exchange in patients with severe viral hepatitis

RAO Hui^1, ,,
ZANG Li²

- 1. Department of Clinical Laboratory, Xiangyang Central Hospital, Xiangyang, 441021, China;
- 2. Department of Nephrology, Xiangyang Central Hospital

More Information

Corresponding author: RAO Hui, E-mail: raohui2004@sina.com

Received Date: 10 October 2012

摘要

摘要: 目的：观察血浆置换（PE）治疗重型乙型病毒性肝炎前后血清乙肝病毒（HBV）载量变化及与疗效的关系。方法：对30例重型乙型病毒性肝炎患者进行PE治疗，使用聚合酶链反应（PCR）-荧光探针法检测PE前和PE后第7天的血清HBV-DNA，观察实验室指标和临床疗效。结果：PE可明显降低血清病毒载量（P<0.05），治疗前后HBV-DNA（log值）分别为（6.08±1.81）、（3.72±1.47）。其中治疗有效组22例，病毒载量（log值）由（5.90±1.96）下降到（3.37±1.30），平均下降（3.00±1.74）；治疗无效组8例，病毒载量（log值）由（6.25±1.62）下降到（4.76±1.30），平均下降（1.47±0.43），2组病毒载量变化程度比较差异有统计学意义（P<0.05）。结论：PE可降低重型乙型病毒性肝炎HBV载量，治疗有效组病毒载量下降更明显。
- 血浆置换 /
- 重型肝炎
Abstract: Objective: To observe the change of serum HBV-DNA loads and prognosis before and after plasma exchange (PE) in patients with severe viral hepatitis.Method: The copies of serum HBV DNA were detected by quantitative polymerase chain reaction(FQ-PCR) in the 30 patients with severe viral hepatitis before and on 7th day after the treatment of PE. The laboratory and clinical parameters were observed.Result: PE decreased the serum virus loads obviously(P<0.05).The HBV-DNA (log value) before and after PE were (6.08±1.81) and(3.72±1.47),respectively. The virus loads(log value)of 22 cases of effective treatment group decreased from (5.90±1.96) to (3.37±1.30),the decend average was (3.00±1.74).The virus loads (log value) of 8 cases of ineffective treatment group had a reduction from (6.25±1.62) to (4.76±1.30),the decend average was (1.47±0.43).There was a statistically significant difference between the changes of two groups of viral load (P<0.05).Conclusion: The PE could decrease the serum HBV DNA effectively in patients with severe viral hepatitis. The decrease of virus loads was more obvious in effective treatment group.
- plasma exchange /
- severe viral hepatitis

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参考文献(4)

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