Changes of laboratory indexes and prognosis with severe hepatitis B before and after plasma exchange
-
摘要: 目的:观察血浆置换(PE)治疗病毒性重型肝炎的各项指标变化和临床疗效。方法:随机抽取40例病毒性重型肝炎患者在内科综合治疗的基础上加用PE治疗,对照组35例病毒性重型肝炎患者仅行内科综合治疗,观察PE组治疗前后肝功能、凝血指标变化;比较PE组和对照组临床疗效。结果:实验组治疗后血清胆红素、谷丙转氨酶等明显下降,γ谷氨酰转肽酶和白蛋白未见明显变化;除白陶土部分凝血时间未见明显变化外,凝血指标有所好转;PE组治疗有效率为62.5%,高于对照组(51.4%)(P<0.05)。结论:血浆置换治疗病毒性重型肝炎能明显改善肝功能和凝血功能,提高治疗有效率。Abstract: Objective:To observe the effect of plasma exchange (PE)on indexes of liver and coagulation function and prognosis in patients with severe hepatitis B. Method:Among 75 patients with severe hepatitis B, 40 cases treated with PE on the basic medical therapy ,35 cases were treated with only basic medical therapy as control group. The indexes of liver and coagulation function were assessed. Result:The indexes of bilirubin (Bil) and alanine transaminase (ALT) decreased(P<0. 01)and PTA increased (P<0. 01) after PE. The PE could increase the treat effective rate compare with controls (P<0.05).Conclusion:Plasma exchange might be an effective therapy for severe hepatitis B ,and could improve the liver function and coagulation function and increase the survival rate of patients with severe hepatitis B.
-
Key words:
- severe hepatitis B /
- plasma exchange
-
-
[1] 司东晓,熊勇.重型肝炎治疗新进展[J].中西医结合肝病杂志, 2010, 20(1):59-62.
[2] 中华医学会传染病与寄生虫学分会、肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志,2001,19(1):56-62.
[3] 中华传染病与寄生虫病学会人工肝学组.人工肝支持系统的适应证、禁忌证和疗效判断[J].中华肝脏病杂志,2002, 10(6):405-405.
[4] 金晓华,邱骏,杨炳华,等.肝功能指标在人工肝支持系统治疗前后的动态变化[J].西安交通大学学报(医学版),2004,25(6):597-599.
[5] 王林,王亚娟,胡容,等.人工肝治疗重型肝炎生化指标的改善与预后的关系[J].寄生虫病与感染性疾病,2010,8(4):217-220.
-
计量
- 文章访问数: 162
- PDF下载数: 112
- 施引文献: 0
下载: