甲状腺髓样癌的临床细胞病理学分析

康劲松; 钱坤; 刘利敏; 李钫; 赵雅桐

甲状腺髓样癌的临床细胞病理学分析

- 1 华中科技大学同济医学院附属同济医院外科细胞室(武汉, 430030);
- 2 九江学院医学院附属医院病理科

详细信息

通讯作者: 钱坤,E-mail:287379638@qq.com

中图分类号: R736.1

收稿日期: 2011-10-14

Clinical analyses of medullary thyroid carcinoma through cytopathology

- 1. Surgical Cell Room, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China;
- 2. Department of Pathology, the Affiliated Hospital of Jiujiang Medical College

More Information

Corresponding author: QIAN Kun, E-mail: 287379638@qq.com

Received Date: 14 October 2011

摘要

摘要: 目的:探讨甲状腺髓样癌(MTC)的临床细胞病理学特点及鉴别诊断,提高对甲状腺髓样癌的认识和诊断水平。方法:分析2例经病理组织学证实的甲状腺髓样癌的临床表现及细胞病理学特征,免疫表型。结果:例1男, 56岁,右侧甲状腺结节,随吞咽活动无其他不适, 镜下为梭形细胞,呈束状排列,细胞间见红染的淀粉样物,细胞病理学报告疑MTC,组织病理学诊断为MTC(梭形细胞型),免疫表型CaL(+),TG(-),NES(+);例2女, 35岁,右侧甲状腺结节,质硬,随吞咽活动,镜下为圆形,椭圆形细胞,细胞质少,细胞病理学诊断考虑MTC,组织病理学诊断为MTC(小细胞型),免疫表型:CaL(-) , TG (-),NES(+)。结论:充分掌握MTC的临床细胞病理学特征,结合患者的临床资料,进行总结及复习,能有效地提高诊断水平。
- 甲状腺髓样癌 /
- 临床 /
- 细胞病理学
Abstract: Objective:To investigate the cytopathological features and differential diagnosis of medullary thyroid carcinoma (MTC) in order to deeply understand the MTC and increase the rate of diagnosis. Method:Two patients with MTC diagnosed by histopathological methods were used to analyze the clinical manifestation, cytopathological features and immunophenotype . Result:One 56-year male patient with thyroid nodule which could move with swallowing on right side was examined and diagnosed as MTC(spindle cell type) through cytopathology and histopathology examination. Under microscope, the fusiform cells were arranged in bundles. Red amyloid substance could be seen among the cells. Immunophenotype: CaL(+),TG(-),NES(+). The other 35-year female patient with hard thyroid nodule which could move with swallowing on right side was examined and diagnosed as MTC(small cell type) through cytopathology and histopathology examination. Under microscope, the cell were round or ovale and contained little cytoplasm. Immunophenotype: CaL(-), TG (-),NES(+). Conclusion:The diagnosis level might be greatly improved by sufficiently mastering the clinical cytopathology features of MTC combined with the patient's clinical data and analyzing them.
- medullary thyroid carcinoma /
- clinical /
- cytopathology

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参考文献(5)

[1]	王超,余小蒙,周小鸽.细针吸取细胞病理学在甲状腺肿物诊断中的应用[J].诊断病理学杂志,2005,12(22):385-387.
[2]	中山医科大学病理学教研室,同济医科大学病理学教研室.外科病理学[M].武汉:湖北科学技术出版社,1999:1307-1309.
[3]	马正中,阚秀,刘树范.诊断细胞病理学[M].郑州:河南科学技术出版社,2000:535-537.
[4]	纪小龙.免疫组织化学[M].北京:人民军医出版社,2005:372-375.
[5]	阿里·赛巴斯//杨斌,薛德彬,译.甲状腺细胞病理学Bethesda报告系统[M].北京:北京科学技术出版社,2010:117-127.