Analysis of resistance to coagulase-negative staphylococci separated from sputum culture of elderly patients
-
摘要: 目的：了解老年患者肺部感染凝固酶阴性葡萄球菌（CNS）的分布和耐药情况，指导临床合理选择抗生素。方法：对2010-01-2011-12临床分离菌，采用合肥恒星HX-21型微生物分析仪进行细菌鉴定和药敏分析，纸片扩散法（K-B法）对药敏试验进行补充。结果：300株CNS检出耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）221株（73.7%）。药敏结果显示MRCNS的耐药率显著高于甲氧西林敏感凝固酶阴性葡萄球菌（MSCNS），未检出对万古霉素耐药的CNS菌株。结论：MRCNS的高检出率及多重耐药性逐年增高，给临床治疗及控制医院感染造成极大压力。万古霉素可作为多重耐药CNS感染治疗的首选抗生素。
-
关键词:
- 老年患者 /
- 痰培养 /
- 凝固酶阴性葡萄球菌 /
- 甲氧西林敏感凝固酶阴性葡萄球菌 /
- 耐药性
Abstract: Objective: To understand distribution and resistance to coagulase-negative staphylococci (CNS)of elderly patients with lung infection to guide clinical choice of antibiotics.Method: Clinical stains were isolated from January 2010 to December 2011,bacterial identification and susceptibility analysis were done using Hefei star HX-21 Microbial analyzer,and the disk diffusion method (KB method) was used as susceptibility testing supplement.Result: From 300 CNS 221 strains were identified as methicillin-resistant coagulase-negative staphylococci (MRCNS)(73.7%).Susceptibility results showed that the resistance rate of MRCNS was significantly higher than methicillin-sensitive methicillin coagulase-negative staphylococci (MSCNS).CNS strains resistant to vancomycin were not detected.Conclusion: The MRCNS detection rate is high and multi-drug resistant is increasing year by year,causing great pressure to the clinical treatment and control of hospital infection.Vancomycin could be used as first-choice antibiotics for multi-drug resistant CNS infection.-
Key words:
- elderly patients /
- sputum culture /
- CNS /
- MRCNS /
- resistance
-
-
[1] 常勇杰,郑曦,涂斌,等.当代医学理论与实践[M].北京:中国科学技术出版社,2011:210-218.
[2] 崔巍,陈雷.2007-2009年临床分离病原菌分布与耐药分析[J].中华医院感染学杂志,2011,21(7):1427-1429.
[3] 肖永红, 王进, 朱燕, 等.Mohnarin2008年度全国细菌耐药监测[J].中华医院感染学杂志, 2010, 20(16):2377-2383.
[4] JONES R N, PFALLER M A.In vitro activity of newer fluorquinolones for respiratory tract infestions and emerging patterns of antimicrobial for resistance;date from the sentry antimicrobial surveillance program[J].Clin Infect Dis, 2003, 31:516-523.
-
计量
- 文章访问数: 54
- PDF下载数: 47
- 施引文献: 0
下载: