-
Abstract: Platelet transfusion refractory refers to Platelets are destroying the input of patients,and platelet count failed to increase accordingly,which failed to control due to insufficient number of platelets or platelet hemostatic dysfunction caused by bleeding.Repeated platelet transfusion patients,the incidence of PTR is 30%~70%.Laboratory rapid sensitive antibody screening and identification of the clinical treatment of PTR is essential,the author combines research progress at home and abroad in recent years,the platelet transfusion invalid laboratory examination of comprehensive description of the platelet antibody.
-
Key words:
- platelet /
- transfusion invalid /
- laboratory detection
-
-
[1] 刘竞,李代渝,孟庆宝.输血后紫瘢血小板输注无效[M]//夏琳.临床输血诊疗技术.北京:人民卫生出版社,2008:163-176.
[2] 万唐,刘华,廖勇.血小板反复输注效果评价[J].江西医药,2007,42(12):1185-1186.
[3] 吴基.血小板输血[M]//田兆嵩.临床输血学.北京:人民卫生出版社,1998,31-36.
[4] DAVIS K B,SLICHTER S J,CORASH L.Corrected count increment and percent platelet recovery as measures of posttransfusion platelet response:problems and a solution[J].Transfusion,1999,39:586-592.
[5] HEUER L,BLUMENBERG D.Management of bleeding in a multitransfused patient with positive HLA class I alloantibodies and thromb-ocytopenia associated with platelet dysfunction refractory to transfusion of cross-ma tched platelets[J].Blood Coagul Fibrinolysid,2005,16:287-290.
[6] 刘达庄.血小板血型[M]//王培华.输血技术学.北京:人民卫生出版社,2003:196-204.
[7] ENGELFRIET C P,REESINK H W,LEE K,et al.Detection of platelet-reac-tive antibodies in patients who are refractory to platelet transfusions,and the selection of compatible donors[J].Vox Sanguinis,2003,84:73-88.
[8] KIEFEL V,SANTOSO S,WEISHEIT M,et al.Monoclonal antibody-specific immobilization of platelet antigens(MAIPA):a new tool for the identifi-cation of platelet reactive antibodies[J].Blood,1987,70:1722.
[9] 胡丽华,罗成伟,王琳,等.人类血小板同种抗原系统分型的研究进展[J].血栓与止血学,2002,8(3):126-128.
[10] ENGELFRIE C P,REESINK H W.Detection of platelet-reactive antibodies in patients who are refractory to platelet transfusions and the selection of compatible donors[J].Vox Sang,2003,84:73-88.
[11] DFHLINGERA S,HUMPEB A,CONNORC J.Flow-cytometric screening of platelet antibodies with previously frozen cells[J].J Immunol Methods,2005,297:169-175.
[12] KURZ M,GREINIX H,HIKER P,et al.Specificities of antiplatelet antibodies in multitransfused patients with haematooncological disorders[J].Br J Haematol,1996,95:564-569.
[13] 黄慧,冯明亮,刘达庄.人类血小板同种抗原研究进展[J].中国实验血液学杂志,2006:14(6):1262-1268.
[14] LYMAN S,ASTER R H,VISENTIN G P,et al.Polymorphism of human platelet membrane glycoprotein Ⅱb associated with the Baka/Bakb alloantigen system[J].Blood,1990,75:2343-2348.
[15] OHTO H,MIURA S,ARIGA H.The natural history of maternal immunization against foetal platelet alloantigens[J].Transfus Med,2004,14:399-408.
[16] 赵桐茂.人类血小板抗原(HPA)研究概述[J].中国输血杂志2004,17(2):129-132.
[17] BUGERT P,MCBRIDE S,SMITH G,et al.Microarray-based genotyping for blood groups:comparison of gene array and 5'-nuclease assay techniques with human platelet antigen as a model[J].Transfusion,2005,45:654-659.
[18] KURZ M,KNOBL P,KALHS P,et al.Platelet-reactive HLA antibodies associated with low posttransfusion platelet increments:a comparison between the monoclonal antibody-specific immobilization of platelet antigens assay and the lymphocytotoxicity test[J].Transfusion,2001,41:771-774.
[19] LEE K,GODEAU B,FROMONT P,et al.CD36 deficiency is frequent and can cause platelet immunization in Africans[J].Transfusion,1999,39:873.
[20] KEKOMAKI S,VOLIN L,KOISTINEN P,et al.Successful treatment of platelet transfusion refractoriness:the use of platelet transfusions matched for both human leucocyte antigens(HLA)and human platelet alloantigens(HPA)in alloimmunized patients with leukaemia[J].Eur J Haematol,1998,60:112-118.
-
计量
- 文章访问数: 22
- PDF下载数: 41
- 施引文献: 0
下载: