Abstract: Objective: To discuss the incidence of acute transfusion reaction of hemopathy patients,analyse the causes and make effective preventive measures.Method: Data of the transfusion reactions were collected from 2009 to 2011,to make statistic analysis of patients' transfusion reactions,which were from the feedbacks of our hematology department.Result: Among 14 880 patients who received blood transfusions,transfusion reactions were observed in 210 cases,accounting for 1.41%.The majority of the 106 transfusion-related fatalities were due to febrile nonhemolytic transfusion reaction(FNHTR),which accounts for 0.72%;101 cases were caused by allergic transfusion reactions(ATR),accounting for 0.68%;the minority of the 3 post-transfusion fatalities were due to hemolytic transfusion reactions(HTR),accounting for 0.02%.Besides,the transfusion reaction incidences of leukocyte-depleted CRCs,CRCs,plasma and platelet account for 1.01%、1.80%、1.39% and 1.87%,respectively.Conclusion: The incidence of transfusion reactions of hemopathy patients account for 1.41%,which mainly include FNHTE and ATR.Combined application of medicine before blood transfusion,leukocyte-depleted CRCs and screening of irregular antibody could effectively decrease the adverse transfusion reaction incidence of the hemopathy patients.