Detection of coagulation function of patients with gastric cancer and its clinical significance
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摘要: 目的:讨胃肿瘤患者凝血与纤溶系统功能指标的变化,以及了解胃肿瘤患者凝血与纤溶系统功能改变的意义。方法:用SYSMEX CA-7000全自动血凝分析仪分别测定62例胃肿瘤患者、42例胃间质瘤患者、50例胃平滑肌瘤患者以及46例健康体检者的凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)含量及D-二聚体(D-dimer)水平。结果:肿瘤患者的PT、TT、APTT、FIB与胃间质瘤患者、胃平滑肌瘤患者以及健康体检者相比均显著降低,差异有统计学意义(P<0.05),且D-dimer显著升高,差异有统计学意义;胃间质瘤患者的PT、TT、APTT、FIB与健康体检者相比均降低,差异有统计学意义(P<0.05),且D-dimer升高,差异有统计学意义。结论:肿瘤患者与胃间质瘤患者常伴随高凝与纤溶亢进状态,监测患者体内PT、TT、APTT、FIB及D-dimer变化可有效预防血栓性疾病或出血性疾病的发生具有重要意义以及为临床治疗提供依据。Abstract: Objective:To investigate the changes of functional indicators of coagulation and fibrinolysis system,and understand the significance of functional changes of coagulation and fibrinolysis system in gastric cancer patients.Method:Prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB)content and the D-dimer(D-dimer)levels of 62 patients with gastric cancer,42 patients of gastric stromal tumor,50 patients of gastric leiomyoma and 46 healthy volunteers were detected by SYSMEX CA-7000 automated coagulation analyzer.Result:Compared to gastric stromal tumor patients,gastric leiomyoma patients and healthy subjects, the PT, TT,APTT and FIB levels in gastric cancer patients were significantly reduced and D-dimer was significantly increased, which differences were statistically significant(P<0.05). All indicators in gastric stromal tumors patients were statistically significantly lower than those in healthy subjects(P<0.05).Conclusion:Patients with gastric cancer and gastric stromal tumors were often associated with a hypercoagulable and fibrinolytic state,therefore it was significant to monitor the changes of PT,TT, APTT, FIB and D-dimer in patients for effectively preventing the occurrence of thrombotic disease or bleeding disorders as well as providing a basis for clinical treatment.
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Key words:
- gastric cancer /
- gastric stromal tumors /
- gastric leiomyoma /
- coagulation /
- fibrinolysis
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