Significance of irregular antibody screening of blood recipients for clinical transfusion safety
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摘要: 目的:分析输血前不规则抗体筛查抗体检测的阳性频率及其特异性,探讨不规则抗体筛查阳性时的临床意义,分析输血前的有效处理方法,以确保临床输血安全。方法:对2012-02-2014-02输血或手术备血的7 231例患者应用微珠凝胶技术进行不规则抗体筛查,结果阳性的标本送烟台市中心血站进行抗体鉴定,分析抗体特异性。结果:检出不规则抗体阳性27例,阳性率为0.37%, 其中自身抗体3例,自身抗体和同种抗体同时存在1例,同种抗体23例。结论:输血前不规则抗体筛查对临床安全输血具有重要意义,应用敏感度高的检测方法进行检测, 尽可能检出有临床意义的抗体,以减少输血风险,保证临床输血安全。Abstract: Objective:To detect irregular antibodies in the serum of blood recipients, so as to ensure the safety of clinical blood transfusion. Method:Irregular antibodies of 7231 blood recipients were detected by Micro-tube Gel test from February 2012 to February 2014.The samples with positive results were sent to Yantai Blood Center for antibody identification and antibody specificity analysis. Result:27 cases with irregular antibody were found in 7231 patients, the positive rate of irregular antibodies was 0.37%, of which 3 cases with auto-antibody, 1 cases with auto-antibody and allo-antibodies, and 23 cases with specificity allo-antibody. Conclusion:It would be of great significance to screen irregular antibodies before blood transfusion. High sensitive detection methods should be used for boosting the positive rate of the clinical significant antibodies in order to avoid transfusion reaction and ensure the safety of blood transfusion.
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Key words:
- irregular antibodies /
- transfusion safety
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