Abstract: Objective: To explore the application effect of predeposit autologous blood transfusion in the pregnant women with placenta previa. Method: A total of 83 cases of pregnant women with placenta previa were chosed as the research objects in our hospital between March 2011 and June 2015. All patients received autologous blood collecting 1 to 2 times, 200 ml each time at 3 weeks before cesarean delivering, and autologous blood were refrigerated at 4℃. Blood pressure and heart rate of the pregnant women were monitored, and fetal hearts were monitored and nursed within 30 min before blood collection and within 2 h after blood collection. Blood pressure, heart rate and breathing of the pregnant women were monitored before and after the blood collecting. The blood indexed such as RBC, Hb, Hct, PLT, PT and APTT were analyzed before and after blood collection and autologous blood transfusion respectively. Result: The general situations of the pregnant women and their fetus were stable in the process of blood collection and feedback, and neonatal Apgar scores were 9 to 10 points. No obvious changes happened in blood pressure, heart rate and breathing of the pregnant women before and after blood collection, after delivery (P>0.05). The blood indexed such as RBC, Hb, Hct, PLT, PT and APTT were no significant changes before and after blood collection and autologous blood transfusion.Conclusion: Clinical application of predeposit autologous blood transfusion in the pregnant women with placenta previa may be security, has no ill influence on maternal and infant prognosis, and be of certain clinical application value.