Diagnosis and treatment of nasopharyngeal carcinoma by dynamic detection of EB virus nucleic acid and antibody
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摘要: 目的:探讨EB病毒(EBV)DNA载量及EA(早期抗原)IgG抗体滴度与鼻咽癌的临床关系。方法:以2014-05-2015-05共164例入住武汉协和医院肿瘤中心的鼻咽癌患者为研究对象,其中随机做了外周血EBVDNA病毒载量的为89例,89例中随机又检测EA IgG滴度的为51例,结合鼻咽癌的临床分期进行综合分析。结果:在鼻咽癌的临床初级中级阶段(如T1,N0,M0,Ⅰ),EBV-DNA-初诊阴性组的比例大于初诊阳性组(P<0.05)。在整个鼻咽癌诊疗过程中,EBV-DNA的载量呈现波动性下降趋势。EA IgG与放射标准摄取值(SUV)呈现正相关(P<0.05)。EA IgG的滴度随着临床分级的提升而增高,且差异有统计学意义(P<0.05)。结论:在鼻咽癌的临床初级中级阶段,EBV-DNA的病毒载量检测能提高诊断的准确性,在整个鼻咽癌诊疗过程中,EBVDNA病毒载量的波动性及EA IgG抗体滴度与临床分级/放射标准摄取值的一致性能够指导鼻咽癌的治疗。Abstract: Objective:To discover the relationship between Epstein-Barr virus(EBV) viral load as well as antibody titer of early antigen(EA) IgG and nasopharyngeal carcinoma.Method:EBV load(n=89) and antibody titer of EA IgG(n=51) were examined and the major clinical manifestations of EBV infection was combined for comprehensive analysis from May,2014 to May,2015 in Cancer Center of Union Hospital,Tongji Medical College,Huazhong University of Science and Technology.Result:The proportion of first visit negative EBV-DNA group was larger than that of first visit positive EBV-DNA group during clinical primary and intermediate stage.The viral load showed decreasing trend volatility in the process of the nasopharyngeal carcinoma diagnosis and treatment.EA IgG was of positive relevance with standard uptake value(SUV)(P<0.05).The antibody titer increased with prolonged time of clinic classification(P<0.05).Conclusion:During clinical primary and intermediate stage,the detection of EBV-DNA load can contribute to the diagnosis of EBV infection.Throughout the whole process,the volatility of EBV-DNA load and positive relevance of EA IgG titer with SUV/clinic classification might have certain guiding significance for clinical treatment.
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Key words:
- nasopharyngeal carcinoma /
- Epstein-Barrvirus
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[1] 陈俊妮,吴刚,杨时平,等.诱导化疗±同期放化疗对血浆EBV-DNA>4000copies/ml的 N2-3 M0期鼻咽癌的临床研究[J].中华放射肿瘤学杂志,2017,26(2):123-127.
[2] 周予婧,许雍皞,冯斯斯,等.鼻咽癌病人外周血EBV DNA最低检出限与不同核酸抽提试剂关系的分析[J].实用预防医学,2016,23(12):1409-1411.
[3] 俞霞,季明芳,程伟民,等.EBV抗体和EBV-DNA在鼻咽癌诊断及分期的研究[J].中国肿瘤临床,2016,43(15):650-654.
[4] 管振祺,何凤屏,邱世洁,等.EB病毒DNA定量检测在鼻咽癌临床分期中的诊断价值[J].国际检验医学杂志,2016,37(21):2961-2963.
[5] 郭文杰,陈猛,王德军,等.血浆EBV-DNA定量检测对复发/转移鼻咽癌患者的意义[J].肿瘤学杂志2015,21(5):382-386.
[6] 陈猛,郭文杰,宗丹,等.局部晚期鼻咽癌血浆EBVDNA水平与肿瘤负荷及预后的关系[J].肿瘤学杂志2015,21(3):190-194.
[7] 李中文,汤明,邹彦,血浆EBV-DNA在中晚期鼻咽癌患者中表达水平差异性[J].中国医学创新,2015,12(4):27-30.
[8] 翁敬锦,司勇锋,邓卓霞,等.鼻咽癌复发患者EB病毒DNA及抗体的表达情况及其临床意义[J].广西医学,2016,38(10):1355-1358.
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