Abstract: Objective:To explore the basic situation of apheresis platelet donation in Wenzhou area, and provide reference for the establishment of a stable team of blood donors.Method:The study included 21,113 blood platelet donors who successfully donated platelets during the 2014-2016 period, and using the software of Zhejiang province blood management and control information system BIS2.0, the basic situation of apheresis platelet donation were investigated and analyzed.Result:From 2014 to 2016, apheresis platelet donation population in gender, age, cultural level and professional had different distribution characteristics in Wenzhou region. By gender, male was 19 743 person-time (93.51%), female was 1 370 person-time (6.49%). By age statistics, the number of people aged 26 to 35 came in at 8 199 person-time (38.83%), and 36 to 45 year-old 6 868 person-time (32.53%) came second. According to the degree of literacy, in turn ,the number of high schools and secondary schools was 6 713 person-time (31.79%), college 4 513 person-time (21.38%), an unknown person-time 4 136 person-time (19.59%), the percentage of low-educated blood donors was decreasing year by year. By occupation statistics, the highest number was employees (35.36%), the second number was freelancers (29.90%), and others (19.58%). Between 2014 and 2016, the rate of double platelet donation increased from 4.11% to 20.01%, and there was no statistical difference in the rate of blood donation reaction between 2 therapeutic quantities and 1 therapeutic donor.Conclusion:In Wenzhou area, the apheresis platelet donation crowd was mainly male. The age was mainly distributed between 26 and 45 years of age. Education background was mainly in high school and secondary school. The profession was led by the enterprise staff, and the freelancer second. Women, higher education, students, employees of the institution and double platelet donation might have a lower proportion of blood platelet donors, the future also needs to strengthen the mobilization propaganda and develop a local advertising recruitment strategy to ensure adequate and safe blood supply.