Abstract: Objective:To analyze the situation of voluntary blood donation and the quality of blood offered in Colleges and universities,and provides scientific reference for the recruitment of blood donation in Colleges and universities in the future. Method:The unpaid blood donation of college students from January 1,2012 to December 31,2016 was retrospectively analyzed,and the unqualified rates of ALT,hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)and treponema pallidum(TP)were measured. Result:Blood donation in Colleges and universities accounts for 9.8% of the total number of blood donors in the city,The unqualified rate of HCV was the highest in the unqualified programs for college students' unpaid blood donation,with an average of 0.35%.The unqualified rate of ALT,HBV and TP for college students' unpaid blood donation:0.11%,0.24%,0.18%,were lower than those of other donors,the difference was statistically significant(P<0.05),while HIV and HCV unqualified rates were:0.14%,0.35%,compared with other donors,there was no statistically significant difference(P>0.05).Conclusion:College students are an important part of the unpaid blood donation population in our city.In the propaganda and recruitment of blood donation in colleges and universities,propaganda and education should be strengthened to prevent blood borne diseases so as to improve the quality of blood collection.