The rapeutic effect of azithromycin combined with vitamin A and glycyrrhiza zinc granules on children with mycoplasma pneumoniae pneumonia
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摘要: 目的:观察阿奇霉素联合维生素A(Vit A)与甘草锌颗粒治疗肺炎支原体肺炎(MPP)患儿的临床疗效,及其对患儿血清中丙二醛(MDA)及免疫球蛋白(Ig)水平的影响。方法:选取2017-08—2018-08治疗的MPP患儿102例,按照随机数字表法分为对照组和观察组,每组51例。对照组患儿给予口服阿奇霉素干混悬剂,观察组在对照组基础上给予Vit A及甘草锌颗粒。比较2组患儿的疗效、白介素-6(IL-6)、白介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)、Vit A、锌(Zn)、MDA、IgA、IgG、IgM及不良反应发生率。结果:观察组的有效率为96.08%,明显高于对照组的84.31%(P＜0.05)。治疗前,2组患儿TNF-α、IL-8、IL-6、Vit A、Zn、MDA、IgM、IgG、IgA水平差异无统计学意义(P＞0.05)。治疗2周后,观察组的IgM、IgG、IgA、MDA、TNF-α、IL-8、IL-6水平均低于对照组(P＜0.05)。观察组的Vit A及Zn高于对照组(P＜0.05)。2组患儿不良反应发生率差异无统计学意义(P＞0.05)。结论:采用阿奇霉素联合Vit A与甘草锌颗粒治疗MPP患儿具有良好的临床疗效,可显著减轻患者体内的氧化反应,降低患者的炎症反应,调节机体的免疫功能,且安全性高。Abstract: Objective: To observe the clinical effect of azithromycin combined with vitamin A (Vit A) and glycyrrhiza zinc granule in the treatment of children with mycoplasma pneumoniae pneumonia (MPP) and its effect on the serum levels of malondialdehyde (MDA) and immunoglobulin (Ig) of children with MPP.Method: From August 2017 to August 2018,102 children with MPP were randomly divided into control group (n=51) and observation group (n=51). In the control group,the oral azithromycin dry suspension was given,which was on the basis of Vit A and zinc licorice particles of the control group.The efficacy,interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), Vit A,zinc (Zn), MDA,IgA,IgG,IgM and the incidence of adverse events were observed in the two groups.Result: The effective rate of the observation group was 96.08%,which was significantly higher than that of the control group (84.31%) (P＜0.05). Before treatment,there was no difference in TNF-α,IL-8,IL-6,Vit A,Zn,MDA,IgM,IgG and IgA levels between the two groups (P＞0.05). After 2 weeks of treatment,the levels of IgM,IgG,IgA,MDA,TNF-α,IL-8 and IL-6 in the observation group were lower than those the control group (P＜0.05). Vit A and Zn in the observation group were higher than those of the control group (P＜0.05). There was no difference in the incidence of adverse events between the two groups (P＞0.05). Conclusion: Azithromycin combined with Vit A and glycyrrhiza zinc granules may have good clinical efficacy in treating children with MPP.It can significantly reduce the oxidation reaction in patients with MPP,reduce the inflammatory reaction of patients,regulate the immune function of the body,and be of high safety.
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Key words:
- azithromycin /
- vitamin A /
- glycyrrhiza zinc granules /
- mycoplasma pneumoniae pneumonia
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[1] 董西慧,朴梅花,韩彤妍,等.早产儿维生素A水平及其相关因素[J].中华围产医学杂志,2017,20(12):874-881.
[2] 李莉,李艳.甘草锌颗粒联合酪酸梭菌活菌散治疗小儿迁延性腹泻的临床疗效[J].药物评价研究,2016,39(2):259-262.
[3] 徐元华,王梅.糖尿病肾病患者接受酮酸联合低蛋白饮食后氧化应激损伤程度、RAS活性、足细胞脱落情况的评估[J].海南医学院学报,2016,22(6):551-554.
[4] 李莉,高春雁.红霉素序贯疗法对小儿支原体肺炎患者免疫球蛋白、细胞因子的影响[J].临床肺科杂志,2016,21(4):732-736.
[5] 刘盼盼,毕少丽,汪宏玲,等.阿奇霉素联合甘草锌对支原体肺炎患儿免疫相关指标的影响[J].健康之路,2016,14(11):14-17.
[6] 余丽丽,赵德育.肺炎支原体肺炎发病机制研究进展[J].中国实用儿科杂志,2017,32(3):234-238.
[7] 林洁,骆林胜,黄鹏,等.肺炎支原体感染与小儿咳嗽变异性哮喘的关系及大环内酯类药物治疗的效果分析[J].中华医院感染学杂志,2016,26(12):2843-2845.
[8] 郭辉,葛亮.炎琥宁联合阿奇霉素对支原体肺炎患儿炎性因子及免疫功能的影响[J].海南医学院学报,2017,23(20):2815-2817.
[9] 卢刚,陈宇清,丁凤鸣,等.不同维持剂量阿奇霉素长程治疗对稳定期支气管扩张症患者肺功能和生命质量的影响[J].中国医师进修杂志,2018,41(6):493-497.
[10] 陶恩福.脐带血维生素A水平与新生儿疾病的相关性研究[D].杭州:浙江大学,2017.
[11] 黄娜.维生素A与呼吸系统疾病关系的研究进展[J].国际儿科学杂志,2019,46(7):512-515.
[12] 叶蕾.葡萄糖酸锌治疗支气管肺炎继发腹泻的临床疗效观察[J].基层医学论坛,2015,13(5):638-639.
[13] 王琦婧,俞栋,尹惠梅,等.重症细菌性感染患儿继发抗生素相关性腹泻的临床分析[J].中华医院感染学杂志,2019(8):1214-1217.
[14] 徐凤琴,张琪,毕良学.支气管肺泡灌洗液肺炎支原体核酸联合血清特异性IgM检测对儿童肺炎支原体感染的诊断价值[J].临床肺科杂志,2018,9(1):35-37.
[15] 华伟.30例小儿支气管肺炎免疫球蛋白的测定[J].中西医结合心血管病杂志(电子版),2018,10(19):57-58.
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