恶性血液病化疗后并发间质性肺炎的临床分析

曾惠; 刘黎琼; 郭晓珺; 屠其华; 胡俊斌

doi:10.13201/j.issn.1004-2806.2012.02.021

恶性血液病化疗后并发间质性肺炎的临床分析

- 1 嘉兴市第一医院血液科(浙江嘉兴, 314000);
- 2 广东省深圳市第六人民医院(南山医院)血液科;
- 3 华中科技大学同济医学院附属协和医院血液病研究所

详细信息

通讯作者: 胡俊斌,E-mail:luckyjun@medmail.com.cn

中图分类号: R554.1

收稿日期: 2011-11-07

修回日期: 2012-01-09

Analysis of 36 patients with hematological malignancies associated with interstitial lung disease after chemotherapy

- 1. Department of Hematology, The First Hospital of Jiaxing, 314000, Jiaxing, China;
- 2. Department of Hematology, Shenzhen Sixth People Hospital(Nanshan Hospital);
- 3. Institute of Hemtology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

More Information

Corresponding author: HU Junbin, E-mail: luckyjun@medmail.com.cn

Received Date: 07 November 2011

Revised Date: 09 January 2012

摘要

摘要: 目的:探讨恶性血液病患者并发间质性肺炎的危险因素与预后因素。方法:回顾性研究452例接受标准化疗的恶性血液病患者。结果:452例患者中有36例并发间质性肺炎,发生率为7.96%。粒细胞缺乏≥7 d的患者中,间质性肺炎的发生率为12.75%。并发真菌感染的患者中,间质性肺炎的发生率为40.00%。恶性血液病患者并发间质性肺炎的病死率为55.56%。粒细胞缺乏≥7 d的间质性肺炎患者,病死率达69.23%。并发真菌感染的间质性肺炎患者,病死率为80.00%。14例粒细胞恢复正常者全部存活。加用激素治疗的患者,病死率14.29%。结论:粒细胞缺乏≥7d、真菌感染是恶性血液病患者化疗后并发间质性肺炎的危险因素。粒细胞缺乏≥7d、真菌感染者预后差,粒细胞恢复正常者预后良好,激素治疗可以改善预后。
- 恶性血液病 /
- 间质性肺炎 /
- 粒细胞缺乏 /
- 真菌感染
Abstract: Objective:To examine risk factors and prognosis of interstitial lung disease (ILD) in patients with hematological malignancies. Method:A retrospective study was performed on 452 patients with hematological malignancies who received at least one administration of standard chemotherapy. Result:Thirty-six out of the 452 patients with hematological malignancies were accomplicated with ILD, with the occurrence rate of 7.96% and the mortality rate of 55.56%. The patients with agranulocytosis lasting more than 6 days had the incidence rate of ILD of 12.75%, with a mortality rate of 69.23%. The incidence of ILD was 40.00% in the patients with fungal infections,while the mortality rate was 80.00% in the same group. Fourteen cases with recovered normal neutrophil count were all survival. In patients delivered with glucocorticoid, the mortality rate was 14.29%. Conclusion:Both agranulocytosis lasting more than 6 days and fungal infections are possible risk factors of ILD in patients with hematological malignancies. The prognosis was relatively poor in patients with agranulocytosis lasting more than 6 days and fungal infections.The recovery of granulocyte was essential for a better prognosis. Glucocorticoid could promptly benefit the patients with hematological malignancies accomplicated with ILD.
- hematological malignancies /
- interstitial lung disease /
- agranulocytosis /
- fungal infection

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