微球在非创伤性股骨头坏死血管内凝血中的作用

张彦; 刘述川; 周晋

doi:10.13201/j.issn.1004-2806.2014.01.025

微球在非创伤性股骨头坏死血管内凝血中的作用

- 哈尔滨医科大学附属第一医院血液科(哈尔滨, 150001)

详细信息

通讯作者: 周晋,E-mail:jinzhouh85@163.com

中图分类号: R554

收稿日期: 2012-12-25

Role of micropaticles in the intravascular coagulation of nontraumatic femoral head necrosis

More Information

Corresponding author: ZHOU Jin, E-mail: jinzhouh85@163.com

Received Date: 25 December 2012

摘要

- 微球 /
- 非创伤性股骨头坏死 /
- 血管内凝血
Abstract: The final common pathway in nontraumatic femoral head necrosis is related to intravascular coagulation and microcirculatory thrombsis,which are considered as one of the pathogenesis in nontraumatic necrosis of the femoral head by researchers in the world.Although osteonecrosis may affect all joints of the organism,the femoral head is the most commonly affected.Endothelial cell damage could be followed by abnormal blood coagulation and thrombus formation with any resulting degeneration distal to the site of vascular occlusion.Microparticles (MPs),the subcellular units coated by phospholipid membranes,are released by several cell lines upon activation or apoptosis.MPs could supply a potent procoagulant surface for prothrombinase and tenase formation.Thus MPs actually act as an important factor for the pathogenesis of intravascular coaugulation during nontraumatic femoral head necrosis.In addition,MPs can also transfer cytokines,receptors,RNA and DNA to regulate target cells.The study in the pathogenic role of MPs and the blockage of MPs release or their signal transduction may lead to a novel approach to the treatment of nontraumatic femoral head necrosis.
- micropaticles /
- nontraumatic femoral head necrosis /
- intravascular coagulation

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