CD4<sup>+</sup> CD25<sup>+</sup>调节性T细胞对慢性淋巴细胞白血病预后的影响

陈荣伴; 邹琪

doi:10.13201/j.issn.1004-2806.2015.03.011

CD4⁺ CD25⁺调节性T细胞对慢性淋巴细胞白血病预后的影响

陈荣伴^1, ,,
邹琪²

- 1. 江门市中心医院血液内科(广东江门, 529030);
- 2. 海军陆战学院门诊部

详细信息

通讯作者: 陈荣伴,E-mail:zhchenrongban@163.com

中图分类号: R733.72

收稿日期: 2014-07-31

The significance of CD4⁺ CD25⁺ regulatory T cells for the prognosis of chronic lymphocytic leukemia

CHEN Rongban^1, ,,
ZOU Qi²

- 1. Department of Hematology, Jiangmen Central Hospital, Jiangmen, 529030, China;
- 2. Outpatient Department, Marines School

More Information

Corresponding author: CHEN Rongban, E-mail: zhchenrongban@163.com

Received Date: 31 July 2014

摘要

摘要: 目的:探讨慢性淋巴细胞白血病(CLL)患者外周血CD4⁺CD25⁺调节性T细胞(Treg细胞)表达及其与预后的相关性。方法:采用流式细胞仪检测50例健康者(对照组)及30例CLL患者(CLL组)治疗前后CD4⁺CD25⁺Treg、CD4⁺CD25⁺Foxp3⁺Treg水平。结果:初诊CLL组患者外周血T淋巴细胞数量、CD4⁺CD25⁺Treg、CD4⁺CD25⁺Foxp3⁺Treg水平均显著高于对照组,差异有统计学意义(P<0.05)。治疗后,CLL组患者外周血T淋巴细胞数量、CD4⁺CD25⁺Foxp3⁺Treg水平显著降低,与初诊时比较差异有统计学意义(P<0.05),但仍高于对照组(P<0.05)。CLL患者中,Binet临床分期 A期患者CD4⁺CD25⁺Foxp3⁺Treg水平显著低于B/C期患者,差异有统计学意义(P<0.05)。Spearman相关分析结果显示,Binet临床分期与CD4⁺CD25⁺Foxp3⁺Treg水平呈正相关(r=0.511,P<0.05)。结论:CD4⁺CD25⁺Foxp3⁺Treg水平可能是评估CLL患者预后的有效指标。
- 白血病,淋巴细胞,慢性 /
- 调节性T细胞 /
- 细胞免疫
Abstract: Objective:To evaluate the sifnificance of CD4⁺CD25⁺ regulatory T cells for the prognosis of chronic lymphocytic leukemia.Method:CD4⁺CD25⁺Treg and CD4⁺CD25⁺Foxp3⁺Treg level before and after treatment of 50 cases healthy subjects and 30 cases CLL patients were detected by flow cytometry.Result:The peripheral blood T lymphocytes,CD4⁺CD25⁺Treg and CD4⁺CD25⁺Foxp3⁺Treg levels of initial diagnostic patients were significantly higher than that of healthy group(P<0.05).After treatment,the number of peripheral blood T lymphocytes and CD4⁺CD25⁺Foxp3⁺Treg levels of CLL patients were significantly reduced,compared with initial diagnosis(P<0.05),but still higher than that of healthy group (P<0.05).In CLL group,the CD4⁺CD25⁺Foxp3⁺Treg of patients with Binet stage A significantly lower than patients with Binet stage B/C(P<0.05).Spearman correlation analysis showed that Binet stage was positively correlated with CD4⁺CD25⁺Foxp3⁺Treg levels (r=0.511,P<0.05).Conclusion:CD4⁺CD25⁺Foxp3⁺Treg may be an effective index to evaluate the prognosis of CLL patients.
- chronic lymphocytic leukemia /
- regulatory T cells /
- cellular immune

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