Diagnostic significance of whole blood count parameters in gastric cancer and precancerous lesions
-
摘要: 目的:探讨分析全血细胞计数参数在胃癌及癌前病变中的诊断意义。方法:收集胃癌前病变患者,其中肠化生(AGIM组)49例、低级别上皮内瘤变(LGIN组)80例、高级别上皮内瘤变(HGIN组)87例及胃癌患者(GC组)74例,另选择68例正常健康人员作为对照组(NC组),分析比较不同组别全血细胞参数指标。结果:HGIN组、GC组血小板计数(PLT)、中性粒细胞比值(NRUT)、中性粒细胞/淋巴细胞比值(NLR),与LGIN组、AGIM组比较差异有统计学意义(P＜0.05);GC组PLT、NRUT、NLR,与HGIN组比较差异有统计学意义(P＜0.05);PLT、NRUT、NLR对胃癌前病变、胃癌均具有较高诊断价值。全血细胞参数值(PLT>320×109/L、NRUT>1.5、NLR>4.2)高患者中胃癌发生率高、生存率低。结论:全血细胞参数PLT、NRUT、NLR与胃癌及癌前病变相关,与患者预后存在相关性,建议进一步扩大样本量研究。Abstract: Objective: To explore the diagnostic significance of whole blood cell count parameters in gastric cancer and precancerous lesions.Methods: Patients with gastric precancerous lesions were collected, including 49 patients with intestinal metaplasia(AGIM group), 80 patients with low-grade intraepithelial neoplasia(LGIN group), 87 patients with high-grade intraepithelial neoplasia(HGIN group), and 74 gastric cancer patients(GC group), and 68 normal healthy people were selected as the control(NC group), and the parameters of whole blood cell parameters in different groups were analyzed and compared.Results: Platelet count(PLT), neutrophil ratio(NRUT), neutrophil/lymphocyte ratio(NLR) of HGIN group and GC group were significant different from those of LGIN group and AGIM group(P＜0.05). PLT, NRUT, NLR of GC group were significant different from those of HGIN group(P＜0.05). PLT, NRUT, and NLR had high diagnostic value for gastric precancerous lesions and gastric cancer. Patients with high whole blood cell parameter values(PLT>320×109/L, NRUT>1.5, and NLR>4.2) had a high incidence of gastric cancer and a low survival rate in patients.Conclusion: PLT, NRUT and NLR may be related to gastric cancer and precancerous lesions, and be related to the prognosis of patients. It is recommended to further study with expanding the sample size.
-
Key words:
- gastric cancer /
- precancerous state /
- blood cell analysis /
- parameters /
- diagnosis
-
-
[1] Olmi S,Uccelli M,Oldani A,et al.Laparoscopic Surgery of Gastric Cancer with D2 Lymphadenectomy and Omentum Preservation:Our 10 Years Experience[J].J Laparoendosc Adv Surg Tech A,2020,30(7):749-758.
[2] 国家消化系统疾病临床医学研究中心,中华医学会消化内镜学分会,中华医学会健康管理学分会,等.中国早期胃癌筛查流程专家共识意见(草案)(2017年,上海)[J].中华健康管理学杂志,2018,12(1):8-14.
[3] Ju C,Wen Y,Zhang L,et al.Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer[J].Small,2019,15(49):e1905688.
[4] Li S,Cong X,Gao H,et al.Correction to:Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells[J].J Exp Clin Cancer Res,2019,38(1):177.
[5] 余艳秋,王建宁,翟启智,等.Ki-67、p53、P504 s在胃癌前病变和早期胃癌中的表达及其意义[J].胃肠病学,2018,23(10):591-596.
[6] 房殿春.胃癌前病变的概念、类型、病理特征和临床意义[J].医学与哲学,2015,36(22):9-12.
[7] Chen J,Wu L,Sun Y,et al.Mir-421 in plasma as a potential diagnostic biomarker for precancerous gastric lesions and early gastric cancer[J].PeerJ,2019,7:e7002.
[8] Coletta M,Sami SS,Nachiappan A,et al.Acetic acid chromoendoscopy for the diagnosis of early neoplasia and specialized intestinal metaplasia in Barrett's esophagus:a meta-analysis[J].Gastrointest Endosc,2016,83(1):57-67.e1.
[9] Rodrigues MF,Guerra MR,Alvarenga A,et al.Helicobacter pylori infection and gastric cancer precursor lesions:prevalence and associated factors in a reference laboratory in southeastern brazil[J].Arq Gastroenterol,2019,56(4):419-424.
[10] 付小芬,熊小波.血常规分析肺癌患者血细胞参数的变化及意义[J].检验医学与临床,2017,14(2):274-276.
[11] Xu Z,Xu W,Cheng H,et al.The Prognostic Role of the Platelet-Lymphocytes Ratio in Gastric Cancer:A Meta-Analysis[J].PLoS One,2016,11(9):e0163719.
[12] Hu C,Chen R,Chen W,et al.Thrombocytosis is a significant indictor of hypercoagulability,prognosis and recurrence in gastric cancer[J].Exp Ther Med,2014,8(1):125-132.
[13] Zhao G,Liu N,Wang S,et al.Prognostic significance of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in patients with metastatic gastric cancer[J].Medicine(Baltimore),2020,99(10):e19405.
[14] Shen B,Qian A,Lao W,et al.Relationship between Helicobacter pylori and expression of programmed death-1 and its ligand in gastric intraepithelial neoplasia and early-stage gastric cancer[J].Cancer Manag Res,2019,11:3909-3919.
-
计量
- 文章访问数: 187
- PDF下载数: 281
- 施引文献: 0
下载: