Study on evaluating value of neutrophils/lymphocytes, platelets/lymphocytes and average platelet volume for activity of systemic lupus erythematosus
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摘要: 目的:研究中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、平均血小板体积(MPV)评估系统性红斑狼疮(SLE)活动性的价值。方法:选取2018年1月—2020年6月我院治疗的SLE患者109例(SLE组),根据SLE疾病活动指数(SLE-DAI)分为活动组56例,缓解组53例,另选取健康体检人员56例作为对照组,比较SLE组、对照组,活动组、缓解组间NLR、PLR、MPV、C反应蛋白(CRP)、血沉(ESR)、SLE-DAI、补体C3结果差异,并进行统计分析。结果:SLE组NLR、PLR、MPV、CRP、ESR均高于对照组,补体C3低于对照组(P<0.05);活动组、缓解组、对照组检测指标两两比较差异均有统计学意义(均P<0.05);NLR、PLR、MPV与SLE-DAI均呈正相关,r值分别为0.32、0.19、0.27;NLR、PLR、MPV评估活动性SLE AUC面积分别为0.747、0.696、0.701,最佳截断值分别为4.55、172.51、10.56,纠正混杂因素后,NLR、PLR、MPV均为活动性SLE影响因素,OR分别为2.16、1.45、1.65(P<0.05),根据截断值分层后NLR、PLR、MPV均为活动性SLE影响因素,OR分别为3.51、1.76、2.87(均P<0.05),活动性SLE治疗前后观察指标差异有统计学意义(P<0.05)。结论:NLR、PLR、MPV检测简单、快速,对活动性SLE评估和治疗效果评价具有一定的价值,适合在基层医疗机构推广应用。Abstract: Objective: To study on evaluating the value of neutrophils/lymphocytes, platelets/lymphocytes and average platelet volume for the activity of systemic lupus erythematosus(SLE).Methods: From January 2018 to June 2020, 109 SLE patients treated in our hospital were divided into active group 56 cases, non-active group 53 cases, and 56 cases of healthy persons were selected as control group. Compare the results of NLR, PLR, MPV, C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), SLE-DAI, and complement C3 between the control group, the active group and the inactive group, and the data were stati; stically analyzed.Results: The NLR, PLR, MPV, CRP, ESR in SLE group were higher than those in control group, while complement C3 in SLE group was lower than that in control group(P<0.05), and the differences in the detection indicators of the active group, inactive group, and control group were statistically significant(all P<0.05), NLR, PLR, MPV and SLE-DAI were all positively correlated, with r values were 0.32, 0.19 and 0.27, respectively. NLR, PLR, and MPV assess active SLE AUC areas were 0.747, 0.696 and 0.701, respectively, and the best cut-off values were 4.55, 172.51 and 10.56, respectively. After correcting the confounding factors, NLR, PLR, and MPV were all influencing factors of active SLE, with OR values were 2.16, 1.45, and 1.65 respectively(all P<0.05). According to the cut-off values, NLR, PLR, and MPV were all influencing factors of active SLE, with OR values were 3.51, 1.76, and 2.87(all P<0.05). The differences in the observation indexes before and after active SLE treatment were statistically significant(all P<0.05).Conclusion: The detection of NLR, PLR, and MPV might be simple and fast, and have certain value for the evaluation of active SLE and the evaluation of treatment effect, and be suitable for popularization and application in primary medical institutions.
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Key words:
- systemic lupus erythematosus /
- inflammatory indicators /
- neutrophils /
- lymphocytes /
- platelet
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[1] Kim HA,Jung JY,Suh CH.Usefulness of neutrophil-to-lymphocyte ratio as a biomarker for diagnosing infections in patients with systemic lupus erythematosus[J].Clin Rheumatol,2017,36(11):2479-2485.
[2] 叶青,杜卫星,陶洪,等.脐带间充质干细胞体外调节SLE患者淋巴细胞亚群功能的相关研究[J].现代免疫学,2020,40(4):306-310,315.
[3] 刘静,洪永桃,夏艳辉,等.系统性红斑狼疮伴血小板减少机制及治疗[J].中华风湿病学杂志,2015,19(8):560-563.
[4] 王梅,宋爱凤,曹艳玲,等.初诊系统性红斑狼疮患者血清OC、PINP、CTX、25-OH-VitD与狼疮活动度的相关性分析[J].国际检验医学杂志,2020,41(9):1056-1059.
[5] 郭静,杨瑞,李向花,等.补体C3、C4及C反应蛋白与系统性红斑狼疮疾病活动度的关系[J].宁夏医科大学学报,2016,38(5):554-555.
[6] 覃凤娴,韦维,邹燕,等.中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值及平均血小板体积与系统性红斑狼疮活动度的相关性研究[J].重庆医学,2018,47(18):2428-2431.
[7] Ward MM,Guthrie LC,Alba MI.Clinically important changes in individual and composite measures of rheumatoid arthritis activity:thresholds applicable in clinical trials[J].Ann Rheum Dis,2015,74(9):1691-1696.
[8] 唐仕超,王赓,张志国,等.补体C3、补体C4和C反应蛋白在系统性红斑狼疮活动和感染中的临床价值[J].第二军医大学学报,2016,37(4):397-400.
[9] 林雨薇,陈连.中性粒细胞比例与系统性红斑狼疮肾炎及活动情况相关性[J].中南医学科学杂志,2019,47(2):170-172.
[10] McMillan DC.Systemic inflammation,nutritional status and survival in patients with cancer[J].Curr Opin Clin Nutr Metab Care,2009,12(3):223-226.
[11] 刘光辉,方萍,赵家胜.血小板/淋巴细胞比值和2型糖尿病微血管病的相关性[J].实用医学杂志,2016,32(20):3306-3309.
[12] 邵从军,秦淑国.平均血小板体积/血小板比值与系统性红斑狼疮活动性的相关性分析[J].蚌埠医学院学报,2018,43(1):81-83.
[13] 代荣琴,张金彪.血小板检测参数与系统性红斑狼疮疾病活动的相关性分析[J].中国现代医学杂志,2017,27(5):121-124.
[14] 刘丹,张舒,雷婷,等.血液相关指标与系统性红斑狼疮活动性分析[J].标记免疫分析与临床,2019,26(5):741-744.
[15] Pons-Estel GJ,Saurit V,Alarcón GS,et al.The impact of rural residency on the expression and outcome of systemic lupus erythematosus:data from a multiethnic Latin American cohort[J].Lupus,2012,21(13):1397-1404.
[16] 黄冉冉,徐英英,陈矢.比较中性粒细胞/淋巴细胞、血小板/淋巴细胞和平均血小板体积对早期糖尿病肾病的预测价值[J].中华内分泌外科杂志,2019,13(1):76-80.
[17] 沈薇薇,李宗锋,卜秋宁,等.MPV、PDW、铁蛋白在评估狼疮性肾炎患者肾损伤程度中的价值[J].检验医学,2020,35(1):33-36.
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