Characteristics of ABO/RhD blood group and irregular antibodies in 698 pregnant women
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摘要: 目的:通过分析妊娠妇女ABO/RhD血型及不规则抗体的特征,旨在为孕产妇血型和血液输注提供理论参考。方法:以2020年3月至—2020年6月孕检或待产的698例妊娠妇女为研究对象,入组对象均行ABO/RhD血型检测和不规则抗体检测,分析妊娠妇女ABO/RhD血型和不规则抗体特征,同时分析不规则抗体对妊娠妇女不良妊娠结局的影响。结果:698例妊娠妇女,ABO血型占比分别为:O型30.95%(216/698),A型29.80%(208/698),B型28.80%(201/698),AB型10.46%(73/698),RhD型阴性占比为1.00%(7/698);698例妊娠妇女共检出不规则抗体阳性12例(1.72%),其中不规则抗体阳性分类以抗E(41.67%)、抗Ec(16.67%)较为常见,其次为抗D、抗C、抗c等。年龄>35岁、有输血史的妊娠妇女不规则抗体阳性率较其他年龄段的明显高(P<0.01),不同孕周、不同孕次妊娠妇女不规则抗体阳性率比较差异无统计学意义(P>0.05)。不规则抗体阳性组不良妊娠结局总发生率明显高于不规则抗体阴性组,差异有统计学意义(P<0.01)。结论:妊娠妇女ABO/RhD血型以O、A型常见,而RhD型阴性占比达1.00%,不规则抗体常见类型为IgG类,此外不规则抗体对妊娠妇女不良妊娠结局的影响明显,故而妊娠期或围生期积极进行妊娠妇女ABO/RhD血型的鉴定和不规则抗体的筛查尤为重要。Abstract: Objective: To provide a theoretical basis for blood type identification and blood transfusion of pregnant women through analyzing their ABO/RhD blood group and irregular antibodies.Methods: Between March and June 2020, 698 pregnant women who received pregnancy check-ups or prepared for delivery in the hospital were selected as subjects and tested for ABO/RhD blood group and irregular antibodies. The ABO/RhD blood group and irregular antibodies in pregnant women as well as the influence of irregular antibodies on adverse pregnancy outcome were analyzed.Results: In the 698 pregnant women, the proportions of different blood groups were as follows: type O 30.95%(216/698), type A 29.80%(208/698), type B 28.80%(201/698), type AB 10.46%(73/698), and RhD negative type 1.00%(7/698). Of the 698 pregnant women, 12 had irregular antibodies, accounting for 1.72%(12/698), and anti-E(41.67%) and anti-Ec(16.67%) were more common irregular antibodies, followed by anti-D, anti-C, and anti-c. The positive rate of irregular antibodies was significantly higher in pregnant women>35 years old and having blood transfusion history than that in other age groups(P<0.01). No statistically significant differences were found in the positive rate of irregular antibodies between pregnant women in different gestational weeks and with different times of pregnancy(P>0.05). The total incidence of adverse pregnancy outcomes was significantly higher in the irregular antibody positive group than in the irregular antibody negative group(P<0.01).Conclusion: Type O and type A were common blood groups in pregnant women, and RhD negative type accounted for 1.00%. IgG was a common irregular antibody. In addition, irregular antibodies might have a significant impact on adverse pregnancy outcomes of pregnant women, so it should be particularly important to identify the ABO/RhD blood group and screen irregular antibodies in pregnant women.
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Key words:
- pregnant women /
- ABO blood type /
- RhD blood group /
- irregular antibody
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