血管性血友病因子rs216311基因多态性与慢性心衰并发静脉血栓的相关性研究

宋金萍; 迪力努尔·吾买尔江; 王昌敏

doi:10.13201/j.issn.1004-2806.2021.08.015

血管性血友病因子rs216311基因多态性与慢性心衰并发静脉血栓的相关性研究

- 新疆维吾尔自治区人民医院临床检验中心(乌鲁木齐, 830001)
基金项目:
新疆自治区自然科学基金项目(No:2017D01C140)

详细信息

通讯作者: 王昌敏,E-mail:wcm224@163.com

中图分类号: R394.3

收稿日期: 2020-08-12

Study on correlation between vWF rs216311gene polymorphism and chronic heart failure complicated with venous thrombosis

- Department of Clinical Laboratory, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China

More Information

Corresponding author: WANG Changmin, E-mail: wcm224@163.com

Received Date: 12 August 2020

摘要

摘要: 目的:分析慢性心衰(CHF)患者血管性血友病因子(vWF)基因rs216311多态性与CHF并发静脉血栓的相关性。方法:选取70例CHF患者(心衰组)以及24例CHF并发下肢静脉血栓(并发组)的患者为疾病组,收集患者的一般临床资料,抽取外周血,检测vWF基因rs216311位点多态性及凝血因子活性;采用SPSS 19.0统计学软件,对计量资料进行组间t检验,计数资料进行χ²检验,Logistic回归分析CHF并发静脉血栓的影响因素。结果:和心衰组比较,并发组rs216311多态性位点的基因型和等位基因的分布存在显著差异(P<0.05),且GG型vWF活性显著高于GA型(P<0.05)。回归分析显示vWF rs216311基因型及vWF活性是CHF并发静脉血栓的独立影响因素。结论:vWF rs216311基因型与CHF并发下肢静脉血栓显著相关。
- 慢性心力衰竭 /
- 血管性血友病因子 /
- 单核苷酸多态性 /
- 凝血功能 /
- 静脉血栓
Abstract: Objective: To analyze the causes of hypercoagulable state of chronic heart failure(CHF) by studying the relationship between vWF gene polymorphism and its activity, and explore the mechanism of thrombosis in CHF patients.Methods: A total of 70 patients with CHF and 24 patients with CHF complicated with lower extremity venous thrombosis were included in the disease group. General clinical data of the patient were collected. The polymorphism of the rs216311 locus of the vWF gene was detected. Using the SPSS 19.0 statistical software, one-way variance and t-test were performed on the measurement data, the chi-square test was performed on the count data, and spearman correlation analysis and logistic regression analysis were performed among multiple variables to analyze the risk factors of CHF complicated with venous thrombosis.Results: Compared with the normal control group and the heart failure group, the genotype and allele distribution of the rs216311 polymorphism in the heart failure complicated with thrombus group were significantly different(P<0.05). The activity of vWF rs216311 GG genotype was higher than that of AG type, and the difference of heart failure and thrombosis group was statistically significant. Regression analysis showed that vWF rs216311 genotype and vWF activity were independent risk factors for CHF complicated with venous thrombosis.Conclusion: vWF rs216311 genotype is significantly associated with CHF complicated with lower extremity venous thrombosis.
- chronic heart failure /
- von willebrand factor /
- gene polymorphism /
- coagulation /
- venous thrombosis

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