内蒙古汉族与蒙古族人群Rh血型对比分析调查

乔姝; 余艳琴; 郝金奇; 解彩霞; 吕瑞虹; 郑晓娇

doi:10.13201/j.issn.1004-2806.2023.06.011

内蒙古汉族与蒙古族人群Rh血型对比分析调查

- 1.
  内蒙古科技大学包头医学院第一附属医院输血科(内蒙古包头，014010)
- 2.
  内蒙古科技大学包头医学院公共卫生学院
- 3.
  内蒙古二连浩特市中心医院检验科
基金项目:
内蒙古自治区卫生健康委科研计划项目(No：201703161)

详细信息

通讯作者: 郑晓娇，E-mail：lassi@foxmail.com

中图分类号: R457.1

收稿日期: 2022-09-02

刊出日期: 2023-06-01

Comparative analysis of Rh blood group between Han and Mongolian people in Inner Mongolia

- 1.
  Department of Blood Transfusion, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014010, China
- 2.
  School of Public Health, Baotou Medical College, Inner Mongolia University of Science and Technology
- 3.
  Department of Laboratory, Erlianhot Central Hospital, Inner Mongolia

More Information

Corresponding author: ZHENG Xiaojiao, E-mail: lassi@foxmail.com

Received Date: 02 September 2022

Publish Date: 01 June 2023

摘要

摘要: 目的对内蒙古北部二连浩特市的蒙古族与中部包头市汉族Rh血型系统表型差异性进行研究，为内蒙古不同民族人群输血安全和精准输血提供参考。方法运用微柱凝胶卡式法对内蒙古包头地区汉族住院患者1 026例和二连浩特市医院住院纯蒙古族血统患者506例进行Rh表型血清学分型。结果共检出11种Rh血型表型，汉族以CCDee和CcDEe表型居多，蒙古族CCDee和CcDEe表型居多。蒙古族CcDee表型频率占比高于汉族，ccDEE表型频率低于汉族，差异有统计学差异(P < 0.05)。结论内蒙古纯蒙古族血统患者同汉族患者人群在Rh血型分型上存在差异，蒙古族D、C、c、E、e抗原频率明显高于汉族人群，ee表型明显低于汉族人群，所以蒙古族人群在产生免疫性抗-E抗体频率要低于汉族人群，由抗-E抗体引起的输血反应和新生儿溶血疾病的风险低于汉族人群。
- 内蒙古 /
- 汉族 /
- 蒙古族 /
- Rh血型 /
- 调查
Abstract: Objective To study the phenotypic difference of Rh blood group system between the Mongolian nationality in Erenhot City in northern Inner Mongolia and the Han nationality in Baotou City in central Inner Mongolia, so as to provide a reference for the safety and precision blood transfusion of people in different regions of Inner Mongolia.Methods A total of 1 026 cases of Han nationality in Baotou area of Inner Mongolia and 506 cases of pure Mongolian inpatients in Erenhot City Hospital were selected for serotyping of Rh phenotype.Results A total of 11 Rh blood group phenotypes were detected. The majority of the phenotypes were CCDee and CCDee in Han nationality, while the majority of the phenotypes were CCDee and CCDee in Mongolian nationality. The frequency of CCDee phenotype in Mongolian nationality was much higher than that in Han nationality, and the frequency of CCDee phenotype was much lower than that in Han nationality, and the difference was statistically significant(P < 0.05).Conclusion In northern Inner Mongolia, pure Mongolian crowd have differences in Rh blood type classification, the Mongolian D, C, c, E, e antigen frequency obviously higher than that of the Han people, generally ee phenotypic significantly lower than that of the Han Chinese population, which can be concluded that in the Mongolian people, the frequency of immune anti-E antibodies would be lower than that of the han people, and the risk of transfusion reactions and neonatal hemolytic disorders caused by anti-E antibodies would be lower than that in the Han population.
- Inner Mongolia /
- Han nationality /
- Mongolian nationality /
- Rh blood group /
- survey

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表 1 蒙古族和汉族患者的Rh血型表型分布情况

Rh表型	蒙古族/例	汉族/例	合计/例(%)
RhD(+)			1 523
De-	1	0	1(0.07)
ccDee	7	5	12(0.79)
ccDEe	36	47	83(5.45)
ccDEE	25	93	118(7.75)
CcDee	66	86	152(9.98)
CcDEe	201	388	589(38.67)
CcDEE	1	2	3(0.20)
CCDee	164	395	559(36.70)
CCDEe	4	2	6(0.39)
RhD(-)			9
ccdee	1	3	4(44.44)
Ccdee	0	4	4(44.44)
CcdEe	0	1	1(11.11)
合计	506	1 026	1 532

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表 2 蒙古族和汉族不同性别患者Rh血型分布例

民族	性别	Rh血型分型
民族	性别	De-	ccdee	ccDee	ccDEe	ccDEE	Ccdee	CcdEe	CcDee	CcDEe	CcDEE	CCDee	CCDEe
汉族	男	0	3	4	15	43	1	0	29	153	1	151	0
	女	0	0	1	32	50	3	1	57	235	1	244	2
蒙古族	男	0	1	1	13	9	0	0	26	89	1	64	0
	女	1	0	6	23	16	0	0	40	112	0	100	4

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表 3 不同地区及国家人群Rh表型频率比较 %

Rh表型	本研究	中国北京^[4]	加拿大^[5]	印度北部^[6]	东南亚^[7]
CCDEE	0	0.010	0.010	0.002	0
CCDEe	0.390	0.640	0.200	0.320	1.400
CCDee	36.500	39.820	18.500	40.950	51.800
CcDEe	38.400	37.760	13.300	14.540	30.000
CcDEE	0.200	0.450	0.100	0.400	0.400
CcDee	9.920	9.110	34.900	30.910	8.500
ccDEE	7.700	7.930	2.300	0.780	4.400
ccDEe	5.420	3.440	11.800	3.690	2.500
ccDee	0.780	0.450	2.100	1.150	0.300
CCdee	0	0.010	0	0.050	0.100
Ccdee	0.260	0.140	0.800	2.320	0.100
ccdEe	0	0.010	0.900	0.050	0
ccdee	0.260	0.210	15.100	4.760	0.100
ccdEE	0	0	0	0.004	0
CcdEe	0.070	0	0	0.075	0

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表 4 不同地区及国家人群Rh抗原频率比较 %

Rh抗原	本研究		中国北京^[4]	英国^[8]	印度北部^[6]	沙特^[9]	尼日利亚^[10]
Rh抗原	汉族	蒙古族	中国北京^[4]	英国^[8]	印度北部^[6]	沙特^[9]	尼日利亚^[10]
D	99.22	99.80	99.63	85.0	92.7	84.8	95.0
C	85.58	86.40	87.95	68.0	89.6	62.3	17.7
c	61.31	66.67	59.51	80.0	58.6	74.3	99.8
E	51.94	53.00	50.25	29.0	19.9	23.5	20.5
e	90.74	94.90	91.61	98.0	98.8	95.0	98.7

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