Utilization of platelet-rich plasma together with vacuum sealing drainage for managing intractable diabetic ulcers
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摘要: 目的 运用对照分析的方式，探讨单独采用负压封闭引流技术(VSD)和自体富血小板血浆(PRP)联合VSD技术在处理糖尿病患者难以愈合的伤口方面，两种方案在临床疗效上的区别。方法 选取2022年6月-2023年12月云南省第三人民医院内分泌科收治的糖尿病合并难治性创面患者64例，按治疗方法的不同，分为对照组(32例)和观察组(32例)，对照组实施VSD技术，观察组实施PRP联合VSD技术，对比观察2组患者创面治疗好转率和愈合时间。结果 观察组的伤口治愈情况优于对照组，差异有统计学意义(P < 0.05)；而且观察组的伤口愈合时间短于对照组，差异有统计学意义(P < 0.05)。结论 与VSD比较，PRP联合VSD技术能有效提高创面治疗好转率，缩短愈合时间，疗效更好。Abstract: Objective To discuss the difference of clinical efficacy of vacuum sealing drainage (VSD) and autologous platelet-rich plasma (PRP)combined with VSD in the treatment of intractable wounds in diabetic patients by means of comparative analysis.Methods A group of sixty-four patients with diabetes suffering from persistent wounds, who were admitted to the endocrine department of the hospital from June 2022 to December 2023, were divided into a pair of cohorts, each consisting of 32 individuals.The first cohort underwent conventional VSD therapy, and the second was subjected to a combined treatment of VSD and PRP, according to the distinct treatment plans set for each group. VSD technology was applied to the control group, and PRP combined with VSD technology was applied to the observation group. We assessed the efficacy of treatment by comparing and monitoring the pace of recovery as well as the duration of wound closure between two cohorts.Results Findings indicated that the rate at which wounds closed in the treatment cohort surpassed that of the comparison cohort(P < 0.05), and the period required for complete healing in the treatment cohort was notably reduced compared to the comparison cohort(P < 0.05).Conclusion When PRP was used in conjunction with VSD, it could significantly enhance the rate of wound recovery, reduce the duration of healing, and exhibit a superior therapeutic outcome.
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Key words:
- vacuum sealing drainage /
- autologous platelet rich plasma /
- combination /
- diabetes /
- refractory wounds
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表 1 2组创面治疗好转率的比较
组别 例数 好转/例 无好转/例 治疗好转率/% 对照组 32 24 8 75.0 观察组 32 30 2 93.8 χ2 4.267 P 0.039 
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