造血干细胞捐献者动员采集效果和不良反应的观察

周小玉; 汪承亚; 徐智杰; 孙云雨; 华岚; 熊婷

造血干细胞捐献者动员采集效果和不良反应的观察

- 1 南京医科大学第一附属医院输血科(南京, 210029)

详细信息

通讯作者: 汪承亚,E-mail:wangcylu@126.com

中图分类号: R457

收稿日期: 2012-03-08

Study of healthy donor for hematopoietic stem cell transplantation mobilized by recombinant human granulocyte-colony stimulating factor

- Department of Transfusion Blood, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China

More Information

Corresponding author: WANG Chengya, E-mail: wangcylu@126.com

Received Date: 08 March 2012

摘要

摘要: 目的:探讨中华骨髓库(CDMP)造血干细胞捐献者接受重组人粒细胞集落刺激因子(rhG-CSF)动员后外周血造血干细胞(PBSC)的采集效果及不良反应,关注CDMP 志愿者rhG-CSF有关的不良反应。方法:分析108名正常供者接受rhG-CSF动员后的症状、体征、PBSC采集总量、外周血白细胞计数、CD34⁺细胞比例和肝功能等实验室指标变化及其恢复情况。结果:108名供者接受(5~10)μg/kg体重的rhG-CSF动员后,均获得良好的动员效果。104经1次采集,4经2次采集PBSC达到受体需要的移植细胞量的要求。动员、采集期间供者可耐受动员药物引起的不良反应。但外周血白细胞和ALT的恢复正常的时间最长者达30 d。结论:rhG-CSF可有效动员正常供者的造血干细胞,但应严格采集前的体检和实验室检查,以保证中华骨髓库志愿者造血干细胞捐献的正常进行。
- 重组人粒细胞集落刺激因子 /
- 造血干细胞移植 /
- 供者
Abstract: Objective:To investigate the adverse reactions of the healthy donors mobilized with recombinant human granulocyte-colony stimulating factor(rhG-CSF).Method:A mobilization course in 108 donors for hematopoietic stem cell transplantation(HSCT)was retrospectively studied.Result:All of the donors treated with rhG-CSF(5~10)ug/kg given subcutaneously for five days were well mobilized and the desired CD34⁺ cells for HSCT were obtained after one or two aphereses. The adverse reations of rhG-CSF were well tolerated during the mobilization course in the 108 donors.Conclusion:It was confirmed that rhG-CSF could mobilize the stem cell or progenitor cell to peripheral blood effectively to meet the requirements of HSCT.
- recombinant human granulocyte-colony stimulating factor /
- hematopoietic stem cell transplantation /
- donor

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参考文献(7)

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