抗核抗体和抗心磷脂抗体与特发性血小板减少性紫癜的关系探讨

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收稿日期: 2011-08-01

Study of correlation between antinuclear antibody and anticardiolipin antibody with idiopathic thrombocytopentic purpura

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Received Date: 01 August 2011

摘要: 目的:探讨抗核抗体(ANA)和抗心磷脂抗体(ACA)与特发性血小板减少性紫癜(ITP)的关系。方法:对50例ITP患者及25例健康体检者血清进行ACA和ANA检测。结果:ITP患者ACA和ANA阳性率明显高于对照组,在50例ITP患者中,ACA阳性者15例,阳性率为30%,ANA阳性者17例,阳性率为34%。结论:ACA能与血小板内膜上的磷脂结合,导致血小板消耗性减少。我们应对ANA阳性的ITP患者进行随访,以观察此类患者将来是否发生SLE、RA等自身免疫性疾病。
- 特发性血小板减少性紫癜 /
- 抗核抗体 /
- 抗心磷脂抗体
Abstract: Objective:To approach the correlation between antinuclear antibody(ANA)and anticardiolipin antibody(ACA)with idiopathic thrombocytopenic purpura(ITP). Method:The levels of serum ACA and ANA of 50 patients with ITP and 25 healthy cases were detected. Result: The positive rates of ACA and ANA with ITP were higher than those in the healthy cases. The positive rates of ACA and ANA were 30% and 34% respectively in 50 cases of ITP patients. Conclusion: ACA could combine with phospolipid of platelet membrane,resulting in platelet reduction. We should observe the patients whose ANA are positive,which could be useful in the prognosis of autoimmunity disease,such as SLE,RA.
- idiopathic thrombocytopenic purpura /
- antinuclear antibody /
- anticardiolipin antibody

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