早产儿凝血功能状态分析及输注冷沉淀后疗效观察

唐万兵; 李观强; 陈辉雄; 洪雄新; 张福文; 蔡洁丹; 韦深; 高洪丽; 许耘箔; 李有国

早产儿凝血功能状态分析及输注冷沉淀后疗效观察

- 1 深圳市龙岗区人民医院输血科(广东深圳, 518172);
- 2 深圳市龙岗区人民医院检验科;
- 3 深圳市龙岗区人民医院新生儿科

详细信息

通讯作者: 唐万兵,E-mail:tangwanbing453@163.com

中图分类号: R722

收稿日期: 2011-12-24

Analysis of blood coagulation function condition in premature infants and effect of treatment after cryoprecipitate transfusion

- 1. Department of Transfusion, Longgang District People's Hospital of Shenzhen, Shenzhen, 518172, China;
- 2. Department of Clinical Laboratory, Longgang District People's Hospital of Shenzhen;
- 3. Department of Pediatrics, Longgang District People's Hospital of Shenzhen

More Information

Corresponding author: TANG Wanbing, E-mail: tangwanbing453@163.com

Received Date: 24 December 2011

摘要

摘要: 目的:探讨不同胎龄早产儿凝血功能状态及低纤维蛋白原输注冷沉淀后的疗效分析。方法:①选择 126例早产儿,按胎龄分为<32孕周组、≥ 32~<35孕周组、≥ 35~37孕周组,设50例正常足月新生儿为对照组,在出生后的24 h内检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D)及血小板计数(PLT),分析早产儿凝血功能状态。②对其中55例纤维蛋白原浓度低于0.8 g/L的早产儿进行冷沉淀输注,输注完2 h内测定FIB、PT、APTT、TT、D-D及PLT,并与输注前进行比较分析。结果:①与对照组比较,早产儿 PT、APTT、TT明显增高(P<0.01),FIB明显降低(P<0.01),D-D增高(P<0.05),PLT差异无统计学意义(P>0.05)。②<32孕周组与 ≥ 35~37孕周组比较PT、APTT、TT、D-D增高(P<0.05), FIB降低(P<0.05),PLT无明显差异(P>0.05)。③ 55例早产儿输注冷沉淀后 FIB明显增高(P<0.01),PT、APTT降低(P<0.05),TT、D-D差异无统计学意义(P>0.05)。结论:早产儿凝血功能比正常足月新生儿低下,胎龄越低凝血功能障碍越严重,临床应尽早重视其凝血功能状态;对纤维蛋白原浓度低于0.8 g/L的早产儿应尽早输注冷沉淀,在改善早产儿预后及提高成活率方面具有积极的临床意义。
- 早产儿 /
- 胎龄 /
- 凝血功能 /
- 冷沉淀 /
- 输注 /
- 预后 /
- 成活率
Abstract: Objective:To discuss the blood coagulation function in premature infants with different gestational age, analysis the effect of treatment after cryoprecipitate transfusion in low fibrinogen of premature infants.Method:①The 126 cases were divided into three groups according to gestational age:＜32 weeks group,≥32-＜35 weeks group and ≥35-37 weeks group. Pprothrombin time (PT), part-time activation thromboplastin (APTT),thrombin time (TT), fibrinogen (FIB), D-dimer (D-D) and platelet account(PLT) within after born 24 hours of the three groups and 50 full term infants(control group) were detected, and the condition of blood coagulation function were analyzed.②55 premature infants with low fibrinogen(<0.8 g/L ) were received cryoprecipitate transfusion, and FIB,PT,APTT,TT,D-D within after transfusion 2 hours were detected, and the changes of blood coagulation function were analyzed compared with before transfusion。Result:①Compared with control group,PT, APTT and TT in premature infants group were significantly increased (P＜0.01), FIB was significantly decreased (P＜0.01), D-D was increased (P＜0.05), and PLT was no significantly difference(P＞0.05). ②Compared with ＜35-37 weeks group, PT,APTT,TT and D-D of ＜32 weeks group were increased (P＜0.05), FIB was decreased (P＜0.05), PLT was no significantly difference(P＞0.05). ③Compared with before cryoprecipitate transfusion, the blood coagulation function in 55 premature infants after transfusion, FIB was significantly increased (P＜0.01), PT and APTT decreased (P＜0.05), TT and D-D were no significantly differences(P＞0.05). Conclusion:The blood coagulation function in premature infants was lower than that of full term infants, lower gestational age of the infant was more serious, therefore, clinician should attach importance to blood coagulation function as soon as possible. For premature infants with low fibrinogen(＜0.8 g/L ), it should be received cryoprecipitate transfusion as possible as early, which would be of positive clinical significance in improving prognosis and raising survival rate . [JP]
- premature infant /
- gestational age /
- blood coagulation function /
- cryoprecipitate /
- transfusion /
- prognosis /
- survival rate

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