不规则抗体筛查在临床输血中的分析应用

高志峰; 胡丽华

不规则抗体筛查在临床输血中的分析应用

高志峰,
胡丽华^,

- 华中科技大学同济医学院附属协和医院输血科(武汉, 430022)

详细信息

通讯作者: 胡丽华,E-mail:xhhlh@126.com

中图分类号: R457.1

收稿日期: 2012-04-05

Study of Screening Irregular Antibodies in Clinical Transfusion

GAO Zhifeng,
HU Lihua^,

- Department of Blood Transfusion, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

More Information

Corresponding author: HU Lihua, E-mail: xhhlh@126.com

Received Date: 05 April 2012

摘要

摘要: 目的:分析不规则抗体筛查在临床输血中的应用,降低和避免溶血性输血反应的发生。方法:采用DiaMed微柱凝胶免疫技术(IgG卡)对 20 000例临床住院申请输血患者标本进行不规则抗体筛查,不规则抗体阳性的标本进行抗体鉴定,同时用DiaMed IgG卡进行交叉配血。分析阳性检出者对临床配血的影响。结果:临床住院申请输血患者标本不规则抗体阳性83例,阳性率0.42%。不规则抗体血型系统的鉴定,Rh系统53例,占63.86%;MNSs系统22例,占26.50%;抗-A1 3例,占3.61%;P系统1例,占1.20%;Lewis系统3例,占3.61%;Kell 系统1例,占1.20%。83例不规则抗体阳性标本均用DiaMed IgG卡进行交叉配血,患者均输注了无相应抗原的红细胞。结论:不规则抗体的筛查,对不规则抗体阳性标本鉴定红细胞抗体,能有效降低和避免溶血性输血反应的发生,保证临床输血安全。
- 溶血性输血反应 /
- 不规则抗体 /
- 输血安全
Abstract: Objective:To explore the significance of screening irregular antibodies in clinical transfusion to decrease or avoid hemolytic transfusion reaction.Method:Irregular antibody screening of 20000 samples were detected with Diamed micro column IgG card. Irregular antibody identification of the positive samples was detected and done cross-match with DiaMed micro column IgG card. The specificity and the frequency of occurrence were analyzed and summarize.Result:83 samples were positive of irregular antibody and positive rate was 0.42%.According to the detection of the blood group system of the irregular antibodies,Rh system was 52 cases,accounting for 62.65%;MNSs system 20 cases,accounting for 24.10%;anti-A1 4 cases,accounting for4.82%;P system 2 cases,accounting for 2.41%;Lewis system 3 cases,accounting for 3.61%;and Kell system 2 cases,accounting for 2.41%.Conclusion:Screening of irregular antibodies in patients could decrease or avoid hemolytic transfusion reaction, which would help to ensure the safety of transfusion.
- hemolytic transfusion reaction /
- irregular antibodies /
- safety of blood transfusion

HTML全文

参考文献(6)

[1]	代琼,刘炳,胡伟,等.不规则抗体筛查在临床输血中的应用[J].中国输血杂志,2011,24(7):604-605.
[2]	向东,刘曦,王健莲,等.患者血型不规则抗体的分析[J].中国输血杂志,2005,18(1):22-23.
[3]	肖星甫.输血血液技术手册[M].北京:人民卫生出版社,1985:313-314.
[4]	TAKESHITA A,WATANABE H,FIJIHARA H,et al.Collaborative study of irregular erythrocyte antibodies in Japan:Results from the Japanese study group of allo-immunity and antigen diversity in Asian populations[J].Trans Apher Sci,2010,43:3-8.
[5]	SINGLA S,KUMAR S,ROY K K,et al.Severe hydrops in the infant of a Rhesus D-positive mother due to anti-c antibodies diagnosed antenatally:a case report[J].Med Case Reports,2010,4:57-57.
[6]	夏荣,兰炯采.重视红细胞输注无效,提高临床输血效果[J].中国输血杂志,2008,21(1):5-5.